http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ#Head http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ#assertion http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ#provenance http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ#assertion http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ#_1 http://purl.obolibrary.org/obo/BFO_0000051 http://www.informatics.jax.org/marker/MGI:102760 http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ#_1 http://purl.obolibrary.org/obo/BFO_0000051 http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ#_2 http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ#_1 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/CLO_0002596 http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ#_1 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0043234 http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:101926 http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ#assertion http://www.w3.org/2000/01/rdf-schema#label complex(p(MGI:Dlx5),g(MGI:Star)) http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ#_3 http://www.w3.org/ns/prov#value We examined the effect of Dlx5 expression on the promoter activation of the steroidogenic acute regulatory protein (StAR) gene, which is essential for gonadal and adrenal steroidogenesis, in a Leydig cell line. Dlx5 efficiently activates the StAR promoter when GATA-4, another transcription factor essential for testicular steroidogenesis, was coexpressed. The transcriptional activation required the GATA-4-recognition element in the StAR promoter region and Dlx5 can physically interact with GATA-4. Furthermore, we herein show that the double inactivation of Dlx5 and Dlx6 in the mouse leads to decreased testosterone level and abnormal masculinization phenotype. http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/18276760 http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/18276760 http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ#_3 http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ http://purl.org/dc/terms/created 2014-07-03T14:33:17.468+02:00 http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAVSYsxGrXO8OIuAggtpxDVYiodzZlFF0G3zctZA0uKtQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234