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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAVJyNWR4Dx3TZYwQVspvHnG2xF-SYxLsD2NVwyr3yX2k#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAVJyNWR4Dx3TZYwQVspvHnG2xF-SYxLsD2NVwyr3yX2k#_4 http://www.w3.org/ns/prov#value The combination of the inflammatory cytokines IL-1 beta, TNF-alpha, and IFN-gamma, synergized with Tat to promote the development of angioproliferative KS-like lesions in nude mice that are not observed with each factor alone. Injection of inflammatory cytokines IL-1beta, TNF-alpha and IFN-gamma was found to cause an increase in the expression of bFGF and VEGF. However, bFGF, but not VEGF, synergizes with Tat in vivo and induces endothelial cells to migrate, to adhere, and to grow in response to Tat in vitro. Tat angiogenic effects correlate with the expression of the alpha v beta 3 integrin that is induced by bFGF and binds the arginine-glycine-aspartic acid (RGD) region of Tat. http://www.tkuhn.ch/bel2nanopub/RAVJyNWR4Dx3TZYwQVspvHnG2xF-SYxLsD2NVwyr3yX2k#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10438928 http://www.tkuhn.ch/bel2nanopub/RAVJyNWR4Dx3TZYwQVspvHnG2xF-SYxLsD2NVwyr3yX2k#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAVJyNWR4Dx3TZYwQVspvHnG2xF-SYxLsD2NVwyr3yX2k#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10438928 http://www.tkuhn.ch/bel2nanopub/RAVJyNWR4Dx3TZYwQVspvHnG2xF-SYxLsD2NVwyr3yX2k#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAVJyNWR4Dx3TZYwQVspvHnG2xF-SYxLsD2NVwyr3yX2k#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAVJyNWR4Dx3TZYwQVspvHnG2xF-SYxLsD2NVwyr3yX2k#_4 http://www.tkuhn.ch/bel2nanopub/RAVJyNWR4Dx3TZYwQVspvHnG2xF-SYxLsD2NVwyr3yX2k#pubinfo http://www.tkuhn.ch/bel2nanopub/RAVJyNWR4Dx3TZYwQVspvHnG2xF-SYxLsD2NVwyr3yX2k http://purl.org/dc/terms/created 2014-07-03T14:31:31.427+02:00 http://www.tkuhn.ch/bel2nanopub/RAVJyNWR4Dx3TZYwQVspvHnG2xF-SYxLsD2NVwyr3yX2k http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAVJyNWR4Dx3TZYwQVspvHnG2xF-SYxLsD2NVwyr3yX2k http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234