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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAVFnd1bDzMwE7Pee6MHpwUCYn2pVlrVc_hR5q4rEIpQ8#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAVFnd1bDzMwE7Pee6MHpwUCYn2pVlrVc_hR5q4rEIpQ8#_5 http://www.w3.org/ns/prov#value NF-IL6, a member of the basic leucine zipper (bZIP) family transcription factors, is involved in expression of inducible genes involved in immune and inflammatory responses. We observed that coexpression of oncogenic p21ras stimulated the transactivating activity of NF-IL6 and induced phosphorylation of Thr-235 located just N-terminal to the DNA binding domain of NF-IL6. Recently, mitogen-activated protein (MAP) kinases have been shown to be implicated in the cellular response to activated ras. Purified MAP kinases specifically phosphorylated Thr-235 of NF-IL6 in vitro. Mutation of Thr-235 abolished the ras-dependent activation of NF-IL6. From these results, we conclude that NF-IL6 is regulated through phosphorylation by MAP kinases in response to activated ras. http://www.tkuhn.ch/bel2nanopub/RAVFnd1bDzMwE7Pee6MHpwUCYn2pVlrVc_hR5q4rEIpQ8#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/8384717 http://www.tkuhn.ch/bel2nanopub/RAVFnd1bDzMwE7Pee6MHpwUCYn2pVlrVc_hR5q4rEIpQ8#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAVFnd1bDzMwE7Pee6MHpwUCYn2pVlrVc_hR5q4rEIpQ8#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/8384717 http://www.tkuhn.ch/bel2nanopub/RAVFnd1bDzMwE7Pee6MHpwUCYn2pVlrVc_hR5q4rEIpQ8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAVFnd1bDzMwE7Pee6MHpwUCYn2pVlrVc_hR5q4rEIpQ8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAVFnd1bDzMwE7Pee6MHpwUCYn2pVlrVc_hR5q4rEIpQ8#_5 http://www.tkuhn.ch/bel2nanopub/RAVFnd1bDzMwE7Pee6MHpwUCYn2pVlrVc_hR5q4rEIpQ8#pubinfo http://www.tkuhn.ch/bel2nanopub/RAVFnd1bDzMwE7Pee6MHpwUCYn2pVlrVc_hR5q4rEIpQ8 http://purl.org/dc/terms/created 2014-07-03T14:33:49.709+02:00 http://www.tkuhn.ch/bel2nanopub/RAVFnd1bDzMwE7Pee6MHpwUCYn2pVlrVc_hR5q4rEIpQ8 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAVFnd1bDzMwE7Pee6MHpwUCYn2pVlrVc_hR5q4rEIpQ8 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234