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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAVEid3j_FORNOB5vazO7nvdjBZOfz9vjGishP_qEPXEM#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAVEid3j_FORNOB5vazO7nvdjBZOfz9vjGishP_qEPXEM#_3 http://www.w3.org/ns/prov#value Microarray analysis of the transcriptome of H1975 cells treated with BMS-690514 or CDDP. H1975 cells were treated with either 5 µmol/L (1 µmol/L) BMS-690514 and 50 µmol/L (25 µmol/L) CDDP for 24 h (48 h) and subjected to RNA isolation. Total RNA was then retrotranscribed into double-stranded cDNA followed by T7 RNA polymerase?mediated linear amplification, labeling, and hybridization to a human whole genome 44k oligonucleotide array. Samples from treated cultures were compared with cRNAs obtained through the same procedure from untreated cells. From Supplementary Table S1, which contains a complete list of genes that are transcriptionally modulated by BMS-690514 by a factor higher than 2. n.s., nonstatistically significant P value (>10?5). H1975 cells have a secondary somatic EGFR mutation T790M which confers resistance to erlotinib. BMS-690514, a novel panHER/VEGFR inhibitor described here, exerted antiproliferative and pro-apoptotic effects on NSCLC cell lines, with prominent efficacy on H1975 cells expressing the T790M mutation.(I included only 24h time points-JSP) http://www.tkuhn.ch/bel2nanopub/RAVEid3j_FORNOB5vazO7nvdjBZOfz9vjGishP_qEPXEM#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17616683 http://www.tkuhn.ch/bel2nanopub/RAVEid3j_FORNOB5vazO7nvdjBZOfz9vjGishP_qEPXEM#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAVEid3j_FORNOB5vazO7nvdjBZOfz9vjGishP_qEPXEM#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17616683 http://www.tkuhn.ch/bel2nanopub/RAVEid3j_FORNOB5vazO7nvdjBZOfz9vjGishP_qEPXEM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAVEid3j_FORNOB5vazO7nvdjBZOfz9vjGishP_qEPXEM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAVEid3j_FORNOB5vazO7nvdjBZOfz9vjGishP_qEPXEM#_3 http://www.tkuhn.ch/bel2nanopub/RAVEid3j_FORNOB5vazO7nvdjBZOfz9vjGishP_qEPXEM#pubinfo http://www.tkuhn.ch/bel2nanopub/RAVEid3j_FORNOB5vazO7nvdjBZOfz9vjGishP_qEPXEM http://purl.org/dc/terms/created 2014-07-03T14:33:11.748+02:00 http://www.tkuhn.ch/bel2nanopub/RAVEid3j_FORNOB5vazO7nvdjBZOfz9vjGishP_qEPXEM http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAVEid3j_FORNOB5vazO7nvdjBZOfz9vjGishP_qEPXEM http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234