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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAVDFGjCyceM08yJGyTf0CwUgxccqwAoJrOe0n0g7M6Rs#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAVDFGjCyceM08yJGyTf0CwUgxccqwAoJrOe0n0g7M6Rs#_4 http://www.w3.org/ns/prov#value MUC5AC mucin was measured in cell lysates (filled columns) and in cell supernatants (open columns) by ELISA in confluent cultures of human airway (NCI-H292) epithelial cells incubated for 24 h with medium alone (?TGF-alpha; control), medium alone + 5 ?g/ml of ICAM-1 neutralizing antibody (Ab) (which prevents ligand binding to the first extracellular domain of ICAM-1), or with added TGF-alpha (5 ng/ml; +TGF-alpha) + increasing concentrations of an ICAM-1 neutralizing antibody or + an isotype-matched control antibody (IgG1; 5 ?g/ml). The EGFR ligand TGF-alpha (5 ng/ml, 24 h) increased mucin production 3.5-fold in human airway (NCI-H292) epithelial cells (Fig. 1A). 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