. . . . . . . . . . . . . . . . "p(HGNC:TGFA) -> p(HGNC:MUC5AC)" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "MUC5AC mucin was measured in cell lysates (filled columns) and in cell supernatants (open columns) by ELISA in confluent cultures of human airway (NCI-H292) epithelial cells incubated for 24 h with medium alone (?TGF-alpha; control), medium alone + 5 ?g/ml of ICAM-1 neutralizing antibody (Ab) (which prevents ligand binding to the first extracellular domain of ICAM-1), or with added TGF-alpha (5 ng/ml; +TGF-alpha) + increasing concentrations of an ICAM-1 neutralizing antibody or + an isotype-matched control antibody (IgG1; 5 ?g/ml). The EGFR ligand TGF-alpha (5 ng/ml, 24 h) increased mucin production 3.5-fold in human airway (NCI-H292) epithelial cells (Fig. 1A). An ICAM-1 neutralizing antibody that prevents ICAM-1 ligand binding to the first extracellular domain of ICAM-1 decreased TGF-alpha-induced mucin production dose-dependently by 60% (Fig. 1A)." . . "Selventa" . . . . "2014-07-03T14:33:34.726+02:00"^^ . . .