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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAUxiI0ZJlyMuKY92PJFvsnW-hZzc9GJ2RMg9WuKtY3Os#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAUxiI0ZJlyMuKY92PJFvsnW-hZzc9GJ2RMg9WuKtY3Os#_3 http://www.w3.org/ns/prov#value In contrast, anti-CD3 mAb stimulation without exogenous IL-12 induced a large amount of IFN-{gamma} (68.5 (5.0) ng/ml), as well as marked expression of T-bet (fig 3AGo–C). The level of T-bet induction by anti-CD3 mAb stimulation was not significantly different among CD4+ PBMCs from CD or UC patients, or NL (fig 3BGo). Consistent with mRNA expression, T-bet protein was augmented by anti-CD3 mAb stimulation in CD4+ PBMCs from patients with CD (fig 3CGo; similarly in UC and NL, but data not shown). Furthermore, in parallel with T-bet induction by anti-CD3 mAb stimulation, IL-12Rß2 was also induced in CD4+ PBMCs (fig 3DGo) and additional stimulation by IL-12 induced a fivefold greater amount of IFN-{gamma} (355.0 (62.2) ng/ml) than anti-CD3 mAb stimulation alone (fig 3AGo). http://www.tkuhn.ch/bel2nanopub/RAUxiI0ZJlyMuKY92PJFvsnW-hZzc9GJ2RMg9WuKtY3Os#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15306590 http://www.tkuhn.ch/bel2nanopub/RAUxiI0ZJlyMuKY92PJFvsnW-hZzc9GJ2RMg9WuKtY3Os#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAUxiI0ZJlyMuKY92PJFvsnW-hZzc9GJ2RMg9WuKtY3Os#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15306590 http://www.tkuhn.ch/bel2nanopub/RAUxiI0ZJlyMuKY92PJFvsnW-hZzc9GJ2RMg9WuKtY3Os#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAUxiI0ZJlyMuKY92PJFvsnW-hZzc9GJ2RMg9WuKtY3Os#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAUxiI0ZJlyMuKY92PJFvsnW-hZzc9GJ2RMg9WuKtY3Os#_3 http://www.tkuhn.ch/bel2nanopub/RAUxiI0ZJlyMuKY92PJFvsnW-hZzc9GJ2RMg9WuKtY3Os#pubinfo http://www.tkuhn.ch/bel2nanopub/RAUxiI0ZJlyMuKY92PJFvsnW-hZzc9GJ2RMg9WuKtY3Os http://purl.org/dc/terms/created 2014-07-03T14:32:27.047+02:00 http://www.tkuhn.ch/bel2nanopub/RAUxiI0ZJlyMuKY92PJFvsnW-hZzc9GJ2RMg9WuKtY3Os http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAUxiI0ZJlyMuKY92PJFvsnW-hZzc9GJ2RMg9WuKtY3Os http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234