@prefix this: <
http://www.tkuhn.ch/bel2nanopub/RAUuK0fgUySNJZ57IJ_75llwI3yHvY2iYtAGrLstryECk
> .
@prefix sub: <
http://www.tkuhn.ch/bel2nanopub/RAUuK0fgUySNJZ57IJ_75llwI3yHvY2iYtAGrLstryECk#
> .
@prefix beldoc: <
http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel
> .
@prefix rdfs: <
http://www.w3.org/2000/01/rdf-schema#
> .
@prefix rdf: <
http://www.w3.org/1999/02/22-rdf-syntax-ns#
> .
@prefix xsd: <
http://www.w3.org/2001/XMLSchema#
> .
@prefix dct: <
http://purl.org/dc/terms/
> .
@prefix dce: <
http://purl.org/dc/elements/1.1/
> .
@prefix pav: <
http://purl.org/pav/
> .
@prefix np: <
http://www.nanopub.org/nschema#
> .
@prefix belv: <
http://www.selventa.com/vocabulary/
> .
@prefix prov: <
http://www.w3.org/ns/prov#
> .
@prefix go: <
http://amigo.geneontology.org/amigo/term/GO:
> .
@prefix Protein: <
http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080
> .
@prefix hgnc: <
http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=
> .
@prefix geneProductOf: <
http://purl.obolibrary.org/obo/RO_0002204
> .
@prefix hasAgent: <
http://semanticscience.org/resource/SIO_000139
> .
@prefix species: <
http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=
> .
@prefix occursIn: <
http://purl.obolibrary.org/obo/BFO_0000066
> .
@prefix pubmed: <
http://www.ncbi.nlm.nih.gov/pubmed/
> .
@prefix orcid: <
http://orcid.org/
> .
sub:Head
{
this:
np:hasAssertion
sub:assertion
;
np:hasProvenance
sub:provenance
;
np:hasPublicationInfo
sub:pubinfo
;
a
np:Nanopublication
.
}
sub:assertion
{
sub:_1
hasAgent:
sub:_2
;
a
go:0016301
.
sub:_2
geneProductOf:
hgnc:11283
;
a
Protein:
.
sub:_3
hasAgent:
sub:_4
;
a
go:0042789
.
sub:_4
geneProductOf:
hgnc:11364
;
a
Protein:
.
sub:_5
occursIn:
species:9606
;
rdf:object
sub:_3
;
rdf:predicate
belv:increases
;
rdf:subject
sub:_1
;
a
rdf:Statement
.
sub:assertion
rdfs:label
"kin(p(HGNC:SRC)) -> tscript(p(HGNC:STAT3))" .
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sub:provenance
{
beldoc:
dce:description
"Approximately 61,000 statements." ;
dce:rights
"Copyright (c) 2011-2012, Selventa. All rights reserved." ;
dce:title
"BEL Framework Large Corpus Document" ;
pav:authoredBy
sub:_7
;
pav:version
"20131211" .
sub:_6
prov:value
"STAT3 can also cooperate with AKT or MYC to downregulate p21WAF1 expression and prevent cell-cycle arrest or senescence [55,56]. Interestingly, it has also been recently shown that the SRC STAT3 oncogenic pathwaymight inhibit the expression of the p53 gene. Following its activation by the SRC kinase, STAT3 binds to the promoter of the tumor suppressor gene and prevents its expression. STAT3 downregulates the p53 promoter in breast-cancer cells" ;
prov:wasQuotedFrom
pubmed:17118707
.
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prov:hadPrimarySource
pubmed:17118707
;
prov:wasDerivedFrom
beldoc:
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sub:_6
.
}
sub:pubinfo
{
this:
dct:created
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xsd:dateTime
;
pav:createdBy
orcid:0000-0001-6818-334X
,
orcid:0000-0002-1267-0234
.
}