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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAUrIYPtUz4NrWzwUCMfKVcUJ-o9uIYudQCWy9yuIhQKU#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAUrIYPtUz4NrWzwUCMfKVcUJ-o9uIYudQCWy9yuIhQKU#_3 http://www.w3.org/ns/prov#value we show here that there exists a dynamic feedback loop that is triggered by a DNA damage response (DDR) and, which after a delay of several days, locks the cell into an actively maintained state of 'deep' cellular senescence. The essential feature of the loop is that long-term activation of the checkpoint gene CDKN1A (p21) induces mitochondrial dysfunction and production of reactive oxygen species (ROS) through serial signalling through GADD45-MAPK14(p38MAPK)-GRB2-TGFBR2-TGFbeta. These ROS in turn replenish short-lived DNA damage foci and maintain an ongoing DDR. http://www.tkuhn.ch/bel2nanopub/RAUrIYPtUz4NrWzwUCMfKVcUJ-o9uIYudQCWy9yuIhQKU#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/20160708 http://www.tkuhn.ch/bel2nanopub/RAUrIYPtUz4NrWzwUCMfKVcUJ-o9uIYudQCWy9yuIhQKU#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAUrIYPtUz4NrWzwUCMfKVcUJ-o9uIYudQCWy9yuIhQKU#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/20160708 http://www.tkuhn.ch/bel2nanopub/RAUrIYPtUz4NrWzwUCMfKVcUJ-o9uIYudQCWy9yuIhQKU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAUrIYPtUz4NrWzwUCMfKVcUJ-o9uIYudQCWy9yuIhQKU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAUrIYPtUz4NrWzwUCMfKVcUJ-o9uIYudQCWy9yuIhQKU#_3 http://www.tkuhn.ch/bel2nanopub/RAUrIYPtUz4NrWzwUCMfKVcUJ-o9uIYudQCWy9yuIhQKU#pubinfo http://www.tkuhn.ch/bel2nanopub/RAUrIYPtUz4NrWzwUCMfKVcUJ-o9uIYudQCWy9yuIhQKU http://purl.org/dc/terms/created 2014-07-03T14:33:38.681+02:00 http://www.tkuhn.ch/bel2nanopub/RAUrIYPtUz4NrWzwUCMfKVcUJ-o9uIYudQCWy9yuIhQKU http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAUrIYPtUz4NrWzwUCMfKVcUJ-o9uIYudQCWy9yuIhQKU http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234