http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#Head http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#assertion http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#provenance http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#pubinfo http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#assertion http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#_1 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#_2 http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0042789 http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:99421 http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#_3 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:104990 http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697 http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/CL_0000057 http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#_3 http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#_1 http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#assertion http://www.w3.org/2000/01/rdf-schema#label tscript(p(MGI:Nfe2l1)) -> r(MGI:Gclc) http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#_5 http://www.w3.org/ns/prov#value Glutamate-cysteine ligase catalytic subunit (GCLC) is regulated transcriptionally by Nrf1 and Nrf2.tert-Butylhydroquinone (TBH) induces human GCLC via Nrf2-mediated trans activation of the antioxidant-responsive element (ARE). Interestingly, TBH also induces rat GCLC, but the rat GCLC promoter lacks ARE. This study examined the role of Nrf1 and Nrf2 in the transcriptional regulation of rat GCLC. The baseline and TBH-mediated increase in GCLC mRNA levels and rat GCLC promoter activity were lower in Nrf1 and Nrf2 null (F1 and F2) fibroblasts than in wild-type cells.Overexpression of Nrf1 and Nrf2 in respective cells restored the rat GCLC promoter activity and response to TBH but not if the AP-1 and NF-kappaB binding sites were mutated. http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15988009 http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15988009 http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#_5 http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU#pubinfo http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU http://purl.org/dc/terms/created 2014-07-03T14:32:46.705+02:00 http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAUljzqbAixmqLD-2j9bWD5RJKZiL4MmhaSswkSeuW0XU http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234