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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAUbcT1jAm-Z94-wbM-gjVPkCDo-u_0C6VVihTw8P15Sg#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAUbcT1jAm-Z94-wbM-gjVPkCDo-u_0C6VVihTw8P15Sg#_4 http://www.w3.org/ns/prov#value To identify novel proteins that interact with IRS proteins in muscle, a human skeletal muscle cDNA expression library was created in the lambdaEXlox system and probed with baculovirus-produced and tyrosine-phosphorylated human IRS-1. One clone of the 10 clones which was positive through three rounds of screening represented the C terminus of the Western blot analysis of extracts of rat muscle demonstrated co-immunoprecipitation of both IRS-1 and IRS-2 with the skeletal muscle Ca2+-ATPase (SERCA1) and the cardiac muscle isoform (SERCA2). In both cases, injection of insulin stimulated a 2- to 6-fold increase in association of which was maximal within 5 min. In primary cultures of aortic smooth muscle cells and C2C12 cells, the insulin-stimulated interaction between IRS proteins and SERCA1 and -2 was dose-dependent with a maximum induction at 100 nM insulin. http://www.tkuhn.ch/bel2nanopub/RAUbcT1jAm-Z94-wbM-gjVPkCDo-u_0C6VVihTw8P15Sg#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/9295312 http://www.tkuhn.ch/bel2nanopub/RAUbcT1jAm-Z94-wbM-gjVPkCDo-u_0C6VVihTw8P15Sg#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAUbcT1jAm-Z94-wbM-gjVPkCDo-u_0C6VVihTw8P15Sg#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/9295312 http://www.tkuhn.ch/bel2nanopub/RAUbcT1jAm-Z94-wbM-gjVPkCDo-u_0C6VVihTw8P15Sg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAUbcT1jAm-Z94-wbM-gjVPkCDo-u_0C6VVihTw8P15Sg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAUbcT1jAm-Z94-wbM-gjVPkCDo-u_0C6VVihTw8P15Sg#_4 http://www.tkuhn.ch/bel2nanopub/RAUbcT1jAm-Z94-wbM-gjVPkCDo-u_0C6VVihTw8P15Sg#pubinfo http://www.tkuhn.ch/bel2nanopub/RAUbcT1jAm-Z94-wbM-gjVPkCDo-u_0C6VVihTw8P15Sg http://purl.org/dc/terms/created 2014-07-03T14:30:58.799+02:00 http://www.tkuhn.ch/bel2nanopub/RAUbcT1jAm-Z94-wbM-gjVPkCDo-u_0C6VVihTw8P15Sg http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAUbcT1jAm-Z94-wbM-gjVPkCDo-u_0C6VVihTw8P15Sg http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234