@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAUD7YPTvKnv3pIHslpv-dy7Kr4PgOeYkgyjsbg2y06cI> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAUD7YPTvKnv3pIHslpv-dy7Kr4PgOeYkgyjsbg2y06cI#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix proteinModification: <http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000> .
@prefix psimod: <http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasPart: <http://purl.obolibrary.org/obo/BFO_0000051> .
@prefix ProteinComplex: <http://amigo.geneontology.org/amigo/term/GO:0043234> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix pfh: <http://resource.belframework.org/belframework/1.0/namespace/selventa-named-human-protein-families/> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .
sub:Head {
   this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
   sub:_1 belv:variantOf hgnc:1014 ;
    a proteinModification: , psimod:00696 .
  sub:_2 hasPart: sub:_3 , sub:_4 ;
    a ProteinComplex: .
  sub:_3 geneProductOf: hgnc:4566 ;
    a Protein: .
  sub:_4 geneProductOf: hgnc:11187 ;
    a Protein: .
  sub:_5 hasAgent: sub:_6 ;
    a go:0005525 .
  sub:_6 geneProductOf: pfh:RAS%20Family ;
    a Protein: .
  sub:_7 rdf:object sub:_5 ;
    rdf:predicate belv:directlyIncreases ;
    rdf:subject sub:_2 ;
    a rdf:Statement .
  sub:_8 occursIn: species:9606 ;
    rdf:object sub:_7 ;
    rdf:predicate belv:directlyIncreases ;
    rdf:subject sub:_1 ;
    a rdf:Statement .
  sub:assertion rdfs:label "complex(p(HGNC:GRB2),p(HGNC:SOS1)) => gtp(p(PFH:\"RAS Family\"))" , "p(HGNC:BCR,pmod(P,Y,177)) => (complex(p(HGNC:GRB2),p(HGNC:SOS1)) => gtp(p(PFH:\"RAS Family\")))" .
}
sub:provenance {
   beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_10 ;
    pav:version "1.4" .
  sub:_10 rdfs:label "Selventa" .
  sub:_9 prov:value "Tyrosine phosphorylation led to the association of BCR with the RAS guanine nucleotide exchange complex GRB2-SOS in vivo via the GRB2 SH2 domain, linking BCR to RAS signaling (Maru, Y., Peters, K. L., Afar, D. E. H., Shibuya, M., Witte, O. N., and Smithgall, T. E. (1995) Mol. Cell. Biol. 15, 835-842). In the present study, we demonstrate that BCR Tyr-246 and at least one of the closely spaced tyrosine residues, Tyr-279, Tyr-283, and Tyr-289 (3Y cluster), are phosphorylated by FES both in vitro and in 32Pi-labeled cells. Mutagenesis of BCR Tyr-177 to Phe completely abolished FES-induced BCR binding to the GRB2 SH2 domain, identifying Tyr-177 as an additional phosphorylation site for FES." ;
    prov:wasQuotedFrom pubmed:8955135 .
  sub:assertion prov:hadPrimarySource pubmed:8955135 ;
    prov:wasDerivedFrom beldoc: , sub:_9 .
}
sub:pubinfo {
   this: dct:created "2014-07-03T14:30:57.917+02:00"^^xsd:dateTime ;
    pav:createdBy orcid:0000-0001-6818-334X , orcid:0000-0002-1267-0234 .
}