. . . . . . . . . . . . . "p(HGNC:ARAF) -> p(HGNC:MAP2K1)" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "Activation of the mitogen-activated protein kinase cascade is a critical event in mitogenic growth factor signal transduction. Mitogen-activated protein kinase is directly activated by a dual specific kinase. Activation of MEK1 requires the phosphorylation of serine residues 218 and 222. The a-Raf activated by serum stimulation induced activation of MEK1, which is determined by the coupled kinase activity, and immunoprecipitation and yeast-two hybrid analysis showed that MEK1 is direct substrate of a-Raf." . . "Selventa" . . . . "2014-07-03T14:33:50.997+02:00"^^ . . .