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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RATlmjH8DcRSic7K2E3BLL7v8rEZbof9Utkatc1pxKr_U#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RATlmjH8DcRSic7K2E3BLL7v8rEZbof9Utkatc1pxKr_U#_4 http://www.w3.org/ns/prov#value two-dimensional differentiation in-gel electrophoresis of tumors treated with anti-mir-21 and identified the tumor suppressor tropomyosin 1 (TPM1) as a potential mir-21 target. In agreement with this, there is a putative mir-21 binding site at the 3'-untranslated region (3'-UTR) of TPM1 variants V1 and V5. Thus, we cloned the 3'-UTR of TPM1 into a luciferase reporter and found that although mir-21 down-regulated the luciferase activity, anti-mir-21 up-regulated it. http://www.tkuhn.ch/bel2nanopub/RATlmjH8DcRSic7K2E3BLL7v8rEZbof9Utkatc1pxKr_U#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17363372 http://www.tkuhn.ch/bel2nanopub/RATlmjH8DcRSic7K2E3BLL7v8rEZbof9Utkatc1pxKr_U#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RATlmjH8DcRSic7K2E3BLL7v8rEZbof9Utkatc1pxKr_U#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17363372 http://www.tkuhn.ch/bel2nanopub/RATlmjH8DcRSic7K2E3BLL7v8rEZbof9Utkatc1pxKr_U#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RATlmjH8DcRSic7K2E3BLL7v8rEZbof9Utkatc1pxKr_U#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RATlmjH8DcRSic7K2E3BLL7v8rEZbof9Utkatc1pxKr_U#_4 http://www.tkuhn.ch/bel2nanopub/RATlmjH8DcRSic7K2E3BLL7v8rEZbof9Utkatc1pxKr_U#pubinfo http://www.tkuhn.ch/bel2nanopub/RATlmjH8DcRSic7K2E3BLL7v8rEZbof9Utkatc1pxKr_U http://purl.org/dc/terms/created 2014-07-03T14:33:09.534+02:00 http://www.tkuhn.ch/bel2nanopub/RATlmjH8DcRSic7K2E3BLL7v8rEZbof9Utkatc1pxKr_U http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RATlmjH8DcRSic7K2E3BLL7v8rEZbof9Utkatc1pxKr_U http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234