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<http://bio2rdf.org/drugbank:DB04991_nanopub.RAThbUPgCqg6TngTWKDEftwJPEkpCKR5F-IBvIap7xK18> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.nanopub.org/nschema#Nanopublication> <http://bio2rdf.org/drugbank:DB04991_nanopub.RAThbUPgCqg6TngTWKDEftwJPEkpCKR5F-IBvIap7xK18#head> .
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<http://bio2rdf.org/drugbank:DB04991> <http://purl.org/dc/terms/description> "XL784 is a potent inhibitor of the ADAM-10 metalloprotease enzyme, a target of significant interest because of its important role in blood vessel formation and cell proliferation. XL784 was specifically optimized to be MMP-1 sparing, thus potentially enhancing its safety profile and enabling higher dosing compared with other previously studied metalloprotease inhibitors. Results of single dose Phase I clinical trials of XL784 administered orally to 96 healthy volunteers have demonstrated that XL784 has attractive safety and pharmacokinetic profiles. It is being developed by Exelixis, Inc."@en <http://bio2rdf.org/drugbank:DB04991_nanopub.RAThbUPgCqg6TngTWKDEftwJPEkpCKR5F-IBvIap7xK18#assertion> .
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