http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#Head http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0 http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#assertion http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0 http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#provenance http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0 http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#pubinfo http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#assertion http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#_1 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#_2 http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#_2 http://purl.obolibrary.org/obo/RO_0002204 http://resource.belframework.org/belframework/20131211/namespace/selventa-protein-families/PRKC%20Family http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#_3 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#_4 http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0042789 http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#_4 http://purl.obolibrary.org/obo/BFO_0000051 http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#_5 http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#_4 http://purl.obolibrary.org/obo/BFO_0000051 http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#_6 http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0043234 http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#_5 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=2514 http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#_6 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=11634 http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#_7 http://purl.obolibrary.org/obo/BFO_0000066 http://disease-ontology.org/term/DOID:9538 http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#_7 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#_7 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#_3 http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#_7 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/decreases http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#_7 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#_1 http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#_7 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#assertion http://www.w3.org/2000/01/rdf-schema#label kin(p(SFAM:"PRKC Family")) -| tscript(complex(p(HGNC:CTNNB1),p(HGNC:TCF4))) http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#_9 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#_8 http://www.w3.org/ns/prov#value In addition, enzastaurininduced b-catenin coimmunoprecipitated with its cofactor T-cell factor 4 (Figure S1B), subsequently activating the T-cell factor 4 promoter in MM.1S, HEK293, and HeLa cell lines, as shown by the TOP-FLASH reporter assay (Figure S1C). Taken together, these results demonstrate that enzastaurin triggers accumulation of transcriptionally active b- catenin because of inhibition of its degradation, rather than induced overexpression. http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#_8 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/19018094 http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#_9 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/19018094 http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#_8 http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#pubinfo http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0 http://purl.org/dc/terms/created 2014-07-03T14:33:29.358+02:00 http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234