@prefix this: <http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RATg1oD2VXOlGIVwU7sMaFfkUtFEX4vpdyFRqS0zxS9X0#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix sfam: <http://resource.belframework.org/belframework/20131211/namespace/selventa-protein-families/> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix hasPart: <http://purl.obolibrary.org/obo/BFO_0000051> .
@prefix ProteinComplex: <http://amigo.geneontology.org/amigo/term/GO:0043234> .
@prefix do: <http://disease-ontology.org/term/DOID:> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .
sub:Head {
   this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
   sub:_1 hasAgent: sub:_2 ;
    a go:0016301 .
  sub:_2 geneProductOf: sfam:PRKC%20Family ;
    a Protein: .
  sub:_3 hasAgent: sub:_4 ;
    a go:0042789 .
  sub:_4 hasPart: sub:_5 , sub:_6 ;
    a ProteinComplex: .
  sub:_5 geneProductOf: hgnc:2514 ;
    a Protein: .
  sub:_6 geneProductOf: hgnc:11634 ;
    a Protein: .
  sub:_7 occursIn: do:9538 , species:9606 ;
    rdf:object sub:_3 ;
    rdf:predicate belv:decreases ;
    rdf:subject sub:_1 ;
    a rdf:Statement .
  sub:assertion rdfs:label "kin(p(SFAM:\"PRKC Family\")) -| tscript(complex(p(HGNC:CTNNB1),p(HGNC:TCF4)))" .
}
sub:provenance {
   beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_9 ;
    pav:version "20131211" .
  sub:_8 prov:value "In addition, enzastaurininduced b-catenin coimmunoprecipitated with its cofactor T-cell factor 4 (Figure S1B), subsequently activating the T-cell factor 4 promoter in MM.1S, HEK293, and HeLa cell lines, as shown by the TOP-FLASH reporter assay (Figure S1C). Taken together, these results demonstrate that enzastaurin triggers accumulation of transcriptionally active b- catenin because of inhibition of its degradation, rather than induced overexpression." ;
    prov:wasQuotedFrom pubmed:19018094 .
  sub:_9 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:19018094 ;
    prov:wasDerivedFrom beldoc: , sub:_8 .
}
sub:pubinfo {
   this: dct:created "2014-07-03T14:33:29.358+02:00"^^xsd:dateTime ;
    pav:createdBy orcid:0000-0001-6818-334X , orcid:0000-0002-1267-0234 .
}