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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RATbn0YWsQZrQ3rovmIqWdix_ms7iUVUh03L4p2OYC_BM#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RATbn0YWsQZrQ3rovmIqWdix_ms7iUVUh03L4p2OYC_BM#_3 http://www.w3.org/ns/prov#value Using antisense oligonucleotides, we down-regulated TFDP1 in Hep3B, an HCC cell line that had shown overexpression of the gene, to examine the role of elevated TFDP1 expression in the growth of Hep3B cells. Elevated expression of TFDP1, but not E2F1, was associated significantly with large (> or =5 cm) tumor size (P=0.021). Expression levels of TFDP1 and E2F1 correlated with those of seven transcriptional targets ( TYMS, DHFR, PCNA, RRM1, CCNE1, CDC2, and MYBL2) that play important roles in the G1/S transition, and down-regulation of TFDP1 inhibited growth of Hep3B cells http://www.tkuhn.ch/bel2nanopub/RATbn0YWsQZrQ3rovmIqWdix_ms7iUVUh03L4p2OYC_BM#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/14618416 http://www.tkuhn.ch/bel2nanopub/RATbn0YWsQZrQ3rovmIqWdix_ms7iUVUh03L4p2OYC_BM#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RATbn0YWsQZrQ3rovmIqWdix_ms7iUVUh03L4p2OYC_BM#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/14618416 http://www.tkuhn.ch/bel2nanopub/RATbn0YWsQZrQ3rovmIqWdix_ms7iUVUh03L4p2OYC_BM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RATbn0YWsQZrQ3rovmIqWdix_ms7iUVUh03L4p2OYC_BM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RATbn0YWsQZrQ3rovmIqWdix_ms7iUVUh03L4p2OYC_BM#_3 http://www.tkuhn.ch/bel2nanopub/RATbn0YWsQZrQ3rovmIqWdix_ms7iUVUh03L4p2OYC_BM#pubinfo http://www.tkuhn.ch/bel2nanopub/RATbn0YWsQZrQ3rovmIqWdix_ms7iUVUh03L4p2OYC_BM http://purl.org/dc/terms/created 2014-07-03T14:32:12.099+02:00 http://www.tkuhn.ch/bel2nanopub/RATbn0YWsQZrQ3rovmIqWdix_ms7iUVUh03L4p2OYC_BM http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RATbn0YWsQZrQ3rovmIqWdix_ms7iUVUh03L4p2OYC_BM http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234