sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_5 ;
    pav:version "20131211" .
  sub:_4 prov:value "agonistic antibodies that trigger the receptor Fas (CD95) are unfortunately highly toxic to liver (Ogasawara et al., 1993), TRAIL and agonistic antibodies that bind TRAIL receptors appear to be well tolerated in vivo. synthetic triterpenoids, such as CDDO and CDDOm, that trigger a poorly defined pathway for ubiquitination and degradation of FLIP (Kim et al., 2002; Pedersen et al., 2002), an apoptosis-modulating protein that binds procaspase-8 and -10 (Tschopp et al., 1999).in vitro, these compounds sensitize solid tumor cell lines to TRAIL,and induce apoptosis as single agents in leukemia cells,through a caspase-8-dependent mechanism that remains operative even in chemorefractory cells (Ito et al., 2000; Kim et al., 2002; Pedersen et al., 2002)." ;
    prov:wasQuotedFrom pubmed:12559172 .
  sub:_5 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:12559172 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}