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[These data suggest that this SNP has variable frequency in different ethnic groups. In addition, intraracial differences in allele frequency were seen. The presence of the Val allele in the African-American population, but not in the African population is consistent with the genetic mixing, which has been identified through historical and molecular analysis. However, the presence of many first-generation immigrant populations in the United States provides warning for the overinterpretation of results from any one ethnic group. Therefore, the usefulness of the HER2 SNP in the determination of risk, prognosis, and treatment response of breast cancer will be dramatically different between ethnic populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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