sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_5 ;
    pav:version "20131211" .
  sub:_3 dce:identifier "Biochemistry of Lipids, Lipoproteins and Membranes 2002 - Chapter 16" ;
    dce:title "Biochemistry of Lipids, Lipoproteins and Membranes 2002 - Chapter 16" ;
    dce:type "Book" .
  sub:_4 prov:value "Page 442  Feeding rats with a cholesterol-enriched diet induces bile acid synthesis. This increase is attributable to the rise in cyp7a activity, which catalyzes the rate-limiting step of the classical pathway. Interrupting the return of bile acids to the liver, by diverting bile or by feeding a bile acid-binding resin, also stimulates the synthesis of bile acids.  In contrast, reintroduction of bile acids into bile-diverted rats reverses the stimulatory effect, indicating that bile acid synthesis is subject to end-product inhibition. It was later discovered that cyp7a enzyme activity is closely correlated with cyp7a mRNA abundance, indicating that cyp7a gene transcription is the major determinant of cyp7a activity." ;
    prov:wasQuotedFrom sub:_3 .
  sub:_5 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource sub:_3 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}