dgn-np:NP64598.RAT5pnmdLoVnkRDQm1j2kgt6rlXynPxqGH6bRQ-hQ9U6g130_provenance {
dgn-np:NP64598.RAT5pnmdLoVnkRDQm1j2kgt6rlXynPxqGH6bRQ-hQ9U6g130_assertion dcterms:description "[Compared with control brain, HIV-1 Tg rat brain showed immunoreactivity to glycoprotein 120 and tat HIV-1 viral proteins, and significantly higher protein and mRNA levels of (1) the inflammatory cytokines interleukin-1β and tumor necrosis factor α, (2) the activated microglial/macrophage marker CD11b, (3) AA cascade enzymes: AA-selective Ca2+-dependent cytosolic phospholipase A2 (cPLA2)-IVA, secretory sPLA2-IIA, cyclooxygenase (COX)-2, membrane prostaglandin E2 synthase, 5-lipoxygenase (LOX) and 15-LOX, cytochrome p450 epoxygenase, and (4) transcription factor NF-κBp50 DNA binding activity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en ;
wi:evidence dgn-void:source_evidence_predicted ;
sio:SIO_000772 miriam-pubmed:21846384 ;
prov:wasDerivedFrom dgn-void:rgd-2016 ;
prov:wasGeneratedBy eco:ECO_0000218 .
dgn-void:rgd-2016 pav:importedOn "2016-01-25"^^
xsd:date .
dgn-void:source_evidence_predicted a eco:ECO_0000266 ;
rdfs:comment "Gene-disease associations inferred from animal model manually asserted gene-disease associations."@en ;
rdfs:label "DisGeNET evidence - PREDICTED"@en .
}