. . . . . . . . . . . . . . . . . "kin(p(HGNC:ATM)) => p(HGNC:CHEK1,pmod(P,S,345))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "The basal turnover of Cdc25A operating in unperturbed S phase required Chk1-dependent phosphorylation of serines 123, 178, 278, and 292. IR-induced acceleration of Cdc25A proteolysis correlated with increased phosphate incorporation into these residues generated by a combined action of Chk1 and Chk2 kinases. Finally, phosphorylation of Chk1 by ATM was required to fully accelerate the IR-induced degradation of Cdc25A ... from full text, U2OS cells and ATM-dependent CHEK1 phosphorylation at S317 and S345" . . "Selventa" . . . . "2014-07-03T14:32:00.777+02:00"^^ . . .