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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RASeK3p1kM5V-jC0POqjys8QcpOp6awq9baoF-cPyoZ3Q#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RASeK3p1kM5V-jC0POqjys8QcpOp6awq9baoF-cPyoZ3Q#_5 http://www.w3.org/ns/prov#value Their minimum consensus sequence Hyd-X-R-X-X-(S/T) (where Hyd is any hydrophobic amino acid), determined through peptide studies, provides only a rough template common to many protein kinases (11). Additional specificity is provided by residues adjacent to the phosphorylation site of the substrate, producing differences in substrate preference among these kinases. The differences can have important transcriptional implications; for example, although all three can phosphorylate CREB on the activating site Ser-133, only CaMKII phosphorylates an additional inhibitory site, Ser-142 (13). http://www.tkuhn.ch/bel2nanopub/RASeK3p1kM5V-jC0POqjys8QcpOp6awq9baoF-cPyoZ3Q#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11096122 http://www.tkuhn.ch/bel2nanopub/RASeK3p1kM5V-jC0POqjys8QcpOp6awq9baoF-cPyoZ3Q#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RASeK3p1kM5V-jC0POqjys8QcpOp6awq9baoF-cPyoZ3Q#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11096122 http://www.tkuhn.ch/bel2nanopub/RASeK3p1kM5V-jC0POqjys8QcpOp6awq9baoF-cPyoZ3Q#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RASeK3p1kM5V-jC0POqjys8QcpOp6awq9baoF-cPyoZ3Q#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RASeK3p1kM5V-jC0POqjys8QcpOp6awq9baoF-cPyoZ3Q#_5 http://www.tkuhn.ch/bel2nanopub/RASeK3p1kM5V-jC0POqjys8QcpOp6awq9baoF-cPyoZ3Q#pubinfo http://www.tkuhn.ch/bel2nanopub/RASeK3p1kM5V-jC0POqjys8QcpOp6awq9baoF-cPyoZ3Q http://purl.org/dc/terms/created 2014-07-03T14:31:38.406+02:00 http://www.tkuhn.ch/bel2nanopub/RASeK3p1kM5V-jC0POqjys8QcpOp6awq9baoF-cPyoZ3Q http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RASeK3p1kM5V-jC0POqjys8QcpOp6awq9baoF-cPyoZ3Q http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234