[Whereas alterations of each individual SWI/SNF subunit occurred at modest-frequency, as mutational hills in the genomic landscape, together they affected at least one-third of all pancreatic cancers, defining SWI/SNF as a major mutational mountain. Consistent with a tumor-suppressive role, re-expression of SMARCA4 in SMARCA4-deficient pancreatic cancer cell lines reduced cell growth and promoted senescence, whereas its overexpression in a SWI/SNF-intact line had no such effect.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
Gene-disease associations inferred from text-mining the literature.
DisGeNET evidence - LITERATURE