http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU#Head http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU#assertion http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU#provenance http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU#pubinfo http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU#assertion http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=12428 http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6207 http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/UBERON_0000483 http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU#_2 http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/decreases http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU#_1 http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU#assertion http://www.w3.org/2000/01/rdf-schema#label p(HGNC:TWIST1) -| p(HGNC:JUP) http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU#_4 http://www.w3.org/ns/prov#value This morphological change represents one of the hallmarks of an EMT. To determine whether the molecular alterations of an EMT occurred in these cells, we examined the localization of several adherens junction proteins, such as E-cadherin, alpha-catenin, beta-catenin, and gamma-catenin. Immunostaining showed that all four proteins disappeared from cell membrane in the Twist-express- ing MDCK cells compared to their strong membrane staining in the control cells (Figure 5B). We also observed complete loss of E-cadherin, alpha-catenin, and gamma-catenin proteins by immunoblotting (Figure 5C). In contrast, the expression of fibroblast markers, including fibronectin, vimentin, smooth-muscle actin, and N-cad- herin, whose expression has been shown to correlate positively with the EMT (Boyer and Thiery, 1993), was strongly induced (Figures 5B and 5C). Hence, both the morphological and molecular changes in the Twistexpressing MDCK cells demonstrated that these cells had undergone an EMT. http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15210113 http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15210113 http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU#_4 http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU#pubinfo http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU http://purl.org/dc/terms/created 2014-07-03T14:32:22.806+02:00 http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RASYZbq_IR5uQThGPEjFssiQxGyteW2zQgruIZS8YQweU http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234