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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RASWmKs_zapzcohOEVrFHeX9xu0_iS0ubw5P9-axLyoBc#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RASWmKs_zapzcohOEVrFHeX9xu0_iS0ubw5P9-axLyoBc#_5 http://www.w3.org/ns/prov#value Once stimulated, FAK undergoes autophosphorylation at tyrosine (Y) 397, followed by phosphorylation of several sites including Y576/Y577 which increases FAK's kinase activity, as well as at Y407, Y861, and Y925. Also from full text... Activation of FAK is largely accomplished via its phosphorylation. The initial activation step is autophosphorylation at tyrosine 397 which becomes a site for binding the oncogene Src and the p85 subunit of phosphatidylinositol 3-kinase kinase through their SH2 domains [9]. Subsequently, Y576 and Y577 in the kinase loop are phosphorylated which increases FAK’s catalytic activity. 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