@prefix this: <http://rdf.disgenet.org/nanopublications.trig#NP408274.RASOY9FuRN7DRAu0258JtQgP_YFKo8mfNq6j_T7jII8sE> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix sio: <http://semanticscience.org/resource/> .
@prefix ncit: <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#> .
@prefix lld: <http://linkedlifedata.com/resource/umls/id/> .
@prefix miriam-gene: <http://identifiers.org/ncbigene/> .
@prefix miriam-pubmed: <http://identifiers.org/pubmed/> .
@prefix eco: <http://purl.obolibrary.org/obo/eco.owl#> .
@prefix wi: <http://purl.org/ontology/wi/core#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix pav: <http://purl.org/pav/2.0/> .
@prefix prv: <http://purl.org/net/provenance/ns#> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dgn-np: <http://rdf.disgenet.org/nanopublications.trig#> .
@prefix dgn-gda: <http://rdf.disgenet.org/gene-disease-association.ttl#> .
@prefix dgn-void: <http://rdf.disgenet.org/v2.1.0/void.ttl#> .

dgn-np:NP408274.RASOY9FuRN7DRAu0258JtQgP_YFKo8mfNq6j_T7jII8sE130_head {
  this: np:hasAssertion dgn-np:NP408274.RASOY9FuRN7DRAu0258JtQgP_YFKo8mfNq6j_T7jII8sE130_assertion;
    np:hasProvenance dgn-np:NP408274.RASOY9FuRN7DRAu0258JtQgP_YFKo8mfNq6j_T7jII8sE130_provenance;
    np:hasPublicationInfo dgn-np:NP408274.RASOY9FuRN7DRAu0258JtQgP_YFKo8mfNq6j_T7jII8sE130_publicationInfo;
    a np:Nanopublication .
  
  dgn-np:NP408274.RASOY9FuRN7DRAu0258JtQgP_YFKo8mfNq6j_T7jII8sE130_assertion a np:Assertion .
  
  dgn-np:NP408274.RASOY9FuRN7DRAu0258JtQgP_YFKo8mfNq6j_T7jII8sE130_provenance a np:Provenance .
  
  dgn-np:NP408274.RASOY9FuRN7DRAu0258JtQgP_YFKo8mfNq6j_T7jII8sE130_publicationInfo a
      np:PublicationInfo .
}

dgn-np:NP408274.RASOY9FuRN7DRAu0258JtQgP_YFKo8mfNq6j_T7jII8sE130_assertion {
  miriam-gene:6347 a ncit:C16612 .
  
  lld:C0006118 a ncit:C7057 .
  
  dgn-gda:DGN07966cce2a549c49e2f4bce8ce55c822 sio:SIO_000628 miriam-gene:6347, lld:C0006118;
    a sio:SIO_001121 .
}

dgn-np:NP408274.RASOY9FuRN7DRAu0258JtQgP_YFKo8mfNq6j_T7jII8sE130_provenance {
  dgn-np:NP408274.RASOY9FuRN7DRAu0258JtQgP_YFKo8mfNq6j_T7jII8sE130_assertion dcterms:description
      "[Specifically, we aimed to optimize the therapeutic efficacy of Flt3L/TK treatment in the RG2 model by overexpressing the following genes within the brain tumor microenvironment: 1) a TK mutant with enhanced cytotoxicity (SR39 mutant TK), 2) Flt3L-IgG fusion protein that has a longer half-life, 3) CD40L to stimulate DC maturation, 4) T helper cell type 1 polarizing dendritic cell cytokines interleukin-12 or C-X-C motif ligand 10 chemokine (CXCL)-10, 5) C-C motif ligand 2 chemokine (CCL2) or C-C motif ligand 3 chemokine (CCL3) to enhance dendritic cell recruitment into the tumor microenvironment, 6) T helper cell type 1 cytokines interferon-γ or interleukin-2 to enhance effector T-cell functions, and 7) IκBα or p65RHD (nuclear factor kappa-B [NF-κB] inhibitors) to suppress the function of Foxp3+ Tregs and enhanced effector T-cell functions.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en;
    wi:evidence dgn-void:source_evidence_literature;
    sio:SIO_000772 miriam-pubmed:22996231;
    prov:wasDerivedFrom dgn-void:befree-20140225;
    prov:wasGeneratedBy eco:ECO_0000203 .
  
  dgn-void:befree-20140225 pav:importedOn "2014-02-25"^^xsd:date .
  
  dgn-void:source_evidence_literature a eco:ECO_0000212;
    rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en;
    rdfs:label "DisGeNET evidence - LITERATURE"@en .
}

dgn-np:NP408274.RASOY9FuRN7DRAu0258JtQgP_YFKo8mfNq6j_T7jII8sE130_publicationInfo {
  this: dcterms:created "2014-10-02T12:36:02+02:00"^^xsd:dateTime;
    dcterms:rights <http://opendatacommons.org/licenses/odbl/1.0/>;
    dcterms:rightsHolder dgn-void:IBIGroup;
    dcterms:subject sio:SIO_000983;
    prv:usedData dgn-void:disgenetrdf;
    pav:authoredBy <http://orcid.org/0000-0001-5999-6269>, <http://orcid.org/0000-0002-7534-7661>,
      <http://orcid.org/0000-0002-9383-528X>, <http://orcid.org/0000-0003-0169-8159>, <http://orcid.org/0000-0003-1244-7654>;
    pav:createdBy <http://orcid.org/0000-0003-0169-8159>;
    pav:version "v2.1.0.0" .
  
  dgn-void:disgenetrdf pav:version "v2.1.0" .
}