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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RASMJG-G9E80DUn-S8a6SiZJbGpjKAux-ephJoMIz0eOs#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RASMJG-G9E80DUn-S8a6SiZJbGpjKAux-ephJoMIz0eOs#_5 http://www.w3.org/ns/prov#value As shown in Figure 2A, quiescent A549 cells and HAECs did not have any detectable Rb–Raf-1 interaction, but stimulation with nicotine induced a robust Rb–Raf-1 interaction. The Rb–Raf-1 interaction was detected up to 2 hours after nicotine stimulation and dissipated within 4 hours. The binding between Rb and Raf-1 was also observed in lung cancer cell lines H23, H441, and H226 (Figure 2B) as well as in primary lung cells such as SAECs, NHBEs, and HMEC-Ls stimulated with 1 ?M nicotine (Figure 2C). Nicotine-induced Rb–Raf-1 interaction was abolished by ?-bungarotoxin and MAA, suggesting a role for ?7-nAChR in this binding (Figure 2D). http://www.tkuhn.ch/bel2nanopub/RASMJG-G9E80DUn-S8a6SiZJbGpjKAux-ephJoMIz0eOs#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16862215 http://www.tkuhn.ch/bel2nanopub/RASMJG-G9E80DUn-S8a6SiZJbGpjKAux-ephJoMIz0eOs#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RASMJG-G9E80DUn-S8a6SiZJbGpjKAux-ephJoMIz0eOs#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16862215 http://www.tkuhn.ch/bel2nanopub/RASMJG-G9E80DUn-S8a6SiZJbGpjKAux-ephJoMIz0eOs#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RASMJG-G9E80DUn-S8a6SiZJbGpjKAux-ephJoMIz0eOs#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RASMJG-G9E80DUn-S8a6SiZJbGpjKAux-ephJoMIz0eOs#_5 http://www.tkuhn.ch/bel2nanopub/RASMJG-G9E80DUn-S8a6SiZJbGpjKAux-ephJoMIz0eOs#pubinfo http://www.tkuhn.ch/bel2nanopub/RASMJG-G9E80DUn-S8a6SiZJbGpjKAux-ephJoMIz0eOs http://purl.org/dc/terms/created 2014-07-03T14:33:02.266+02:00 http://www.tkuhn.ch/bel2nanopub/RASMJG-G9E80DUn-S8a6SiZJbGpjKAux-ephJoMIz0eOs http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RASMJG-G9E80DUn-S8a6SiZJbGpjKAux-ephJoMIz0eOs http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234