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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RASCnELQslEmG6LrDgHEyHXSvHF3JD328fS7TyyDyHN7g#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RASCnELQslEmG6LrDgHEyHXSvHF3JD328fS7TyyDyHN7g#_4 http://www.w3.org/ns/prov#value Prokineticin-2 via PKR1 signaling prevents H9c2 cells and cardiomyocytes from apoptosis against hypoxic insult. The H9c2 line of cardioblasts derived from rat heart is known to undergo apoptotic cell death following hypoxia, and is widely used as an in vitro model of ischemic injury to evaluate cardioprotective properties of agents such as erythropoietin (25) . Representative TUNEL (green) and DAPI (blue) stained sections are shown in Fig. 3 A, demonstrating fewer apoptotic cells in the prokineticin-2 pretreated or Adv-PKR1 infected cells (Fig. 3A ).The decrease in apoptotic cells was completely prevented in the presence of PKR1 neutralizing antibody. These results were confirmed by utilizing siRNA for PKR1. In the siRNA-PKR1-transfected, but not in negative control for siRNA transfected cells prokineticin-2 was not able to protect cardiomyocytes against ischemic injury (43±6.6%, n=4), indicating the involvement of PKR1 (Fig. 3A, B ). http://www.tkuhn.ch/bel2nanopub/RASCnELQslEmG6LrDgHEyHXSvHF3JD328fS7TyyDyHN7g#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17442730 http://www.tkuhn.ch/bel2nanopub/RASCnELQslEmG6LrDgHEyHXSvHF3JD328fS7TyyDyHN7g#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RASCnELQslEmG6LrDgHEyHXSvHF3JD328fS7TyyDyHN7g#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17442730 http://www.tkuhn.ch/bel2nanopub/RASCnELQslEmG6LrDgHEyHXSvHF3JD328fS7TyyDyHN7g#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RASCnELQslEmG6LrDgHEyHXSvHF3JD328fS7TyyDyHN7g#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RASCnELQslEmG6LrDgHEyHXSvHF3JD328fS7TyyDyHN7g#_4 http://www.tkuhn.ch/bel2nanopub/RASCnELQslEmG6LrDgHEyHXSvHF3JD328fS7TyyDyHN7g#pubinfo http://www.tkuhn.ch/bel2nanopub/RASCnELQslEmG6LrDgHEyHXSvHF3JD328fS7TyyDyHN7g http://purl.org/dc/terms/created 2014-07-03T14:33:10.129+02:00 http://www.tkuhn.ch/bel2nanopub/RASCnELQslEmG6LrDgHEyHXSvHF3JD328fS7TyyDyHN7g http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RASCnELQslEmG6LrDgHEyHXSvHF3JD328fS7TyyDyHN7g http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234