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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAS0kxoTkoW8n5UW6yaIRjn7wZ1fLXsCpEhWnoKBWRcfI#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAS0kxoTkoW8n5UW6yaIRjn7wZ1fLXsCpEhWnoKBWRcfI#_4 http://www.w3.org/ns/prov#value BACKGROUND: This study describes the functional interaction between the putative Ca2+ channel TRP4 and the cystic fibrosis transmembrane conductance regulator, CFTR, in mouse aorta endothelium (MAEC). RESULTS: MAEC cells express CFTR transcripts as shown by RT-PCR analysis. Application of a phosphorylating cocktail activated a Cl- current with characteristics similar to those of CFTR mediated currents in other cells types (slow activation by cAMP, absence of rectification, block by glibenclamide). The current is present in trp4 +/+ MAEC, but not in trp4 -/- cells, although the expression of CFTR seems unchanged in the trp4 deficient cells as judged from RT-PCR analysis. CONCLUSIONS: It is concluded that TRP4 is necessary for CFTR activation in endothelium, possibly by providing a scaffold for the formation of functional CFTR channels. http://www.tkuhn.ch/bel2nanopub/RAS0kxoTkoW8n5UW6yaIRjn7wZ1fLXsCpEhWnoKBWRcfI#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11356184 http://www.tkuhn.ch/bel2nanopub/RAS0kxoTkoW8n5UW6yaIRjn7wZ1fLXsCpEhWnoKBWRcfI#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAS0kxoTkoW8n5UW6yaIRjn7wZ1fLXsCpEhWnoKBWRcfI#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11356184 http://www.tkuhn.ch/bel2nanopub/RAS0kxoTkoW8n5UW6yaIRjn7wZ1fLXsCpEhWnoKBWRcfI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAS0kxoTkoW8n5UW6yaIRjn7wZ1fLXsCpEhWnoKBWRcfI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAS0kxoTkoW8n5UW6yaIRjn7wZ1fLXsCpEhWnoKBWRcfI#_4 http://www.tkuhn.ch/bel2nanopub/RAS0kxoTkoW8n5UW6yaIRjn7wZ1fLXsCpEhWnoKBWRcfI#pubinfo http://www.tkuhn.ch/bel2nanopub/RAS0kxoTkoW8n5UW6yaIRjn7wZ1fLXsCpEhWnoKBWRcfI http://purl.org/dc/terms/created 2014-07-03T14:31:41.691+02:00 http://www.tkuhn.ch/bel2nanopub/RAS0kxoTkoW8n5UW6yaIRjn7wZ1fLXsCpEhWnoKBWRcfI http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAS0kxoTkoW8n5UW6yaIRjn7wZ1fLXsCpEhWnoKBWRcfI http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234