http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM130_head http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM http://www.nanopub.org/nschema#hasAssertion http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM130_assertion http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM http://www.nanopub.org/nschema#hasProvenance http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM130_provenance http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM http://www.nanopub.org/nschema#hasPublicationInfo http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM130_publicationInfo http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM130_assertion http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Assertion http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM130_provenance http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Provenance http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM130_publicationInfo http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#PublicationInfo http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM130_assertion http://identifiers.org/ncbigene/92521 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16612 http://linkedlifedata.com/resource/umls/id/C0021400 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7057 http://rdf.disgenet.org/resource/gda/DGNa6b5d523946bfa5a3c2f1f2952bb3994 http://semanticscience.org/resource/SIO_000628 http://identifiers.org/ncbigene/92521 http://rdf.disgenet.org/resource/gda/DGNa6b5d523946bfa5a3c2f1f2952bb3994 http://semanticscience.org/resource/SIO_000628 http://linkedlifedata.com/resource/umls/id/C0021400 http://rdf.disgenet.org/resource/gda/DGNa6b5d523946bfa5a3c2f1f2952bb3994 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://semanticscience.org/resource/SIO_001121 http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM130_provenance http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM130_assertion http://purl.org/dc/terms/description [The following observations were made: (i) recent isolates showed an about 2-fold increase in the number of glycosylation sites of HA and NA when compared to isolates from 1968 to 1970; (ii) during passages of clinical strains in CACO-2 and MDCK cells HA and NA mutated cooperatively with strain-specific variations implying that functioning of the HA-NA complex varied from strain to strain in one influenza outbreak; (iii) there were no amino acid exchanges in the HA receptor binding site although the viruses acquired the ability to agglutinate avian erythrocytes after passage in MDCK cells, suggesting that virus adsorption is regulated by several factors; (iv) quasispecies characterized by deletion of 66 nucleotides (22 amino acids) in the stalk region of the NA gene was dominant in naso-pharyngeal washes of all patients whereas during passaging in CACO-2 cells this deleted genotype in isolates from different patients was either stably retained as prevalent quasispecies or rapidly replaced for that one containing full length NA gene; (v) the M2 protein of clinical viruses was sensitive to amantadine; (vi) the NS segment of human viruses, unlike the most of avian ones, contained an additional positive-sense open reading frame encoding a hypothetical 25kD polypeptide (negative strand protein, NSP).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine. http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM130_assertion http://purl.org/ontology/wi/core#evidence http://rdf.disgenet.org/v4.0.0/void/source_evidence_literature http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM130_assertion http://semanticscience.org/resource/SIO_000772 http://identifiers.org/pubmed/19546028 http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM130_assertion http://www.w3.org/ns/prov#wasDerivedFrom http://rdf.disgenet.org/v4.0.0/void/befree-2016 http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM130_assertion http://www.w3.org/ns/prov#wasGeneratedBy http://purl.obolibrary.org/obo/ECO_0000203 http://rdf.disgenet.org/v4.0.0/void/befree-2016 http://purl.org/pav/importedOn 2016-02-19 http://rdf.disgenet.org/v4.0.0/void/source_evidence_literature http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/ECO_0000212 http://rdf.disgenet.org/v4.0.0/void/source_evidence_literature http://www.w3.org/2000/01/rdf-schema#comment Gene-disease associations inferred from text-mining the literature. http://rdf.disgenet.org/v4.0.0/void/source_evidence_literature http://www.w3.org/2000/01/rdf-schema#label DisGeNET evidence - LITERATURE http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM130_publicationInfo http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM http://purl.org/dc/terms/created 2016-05-13T12:47:23+02:00 http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM http://purl.org/dc/terms/rights http://opendatacommons.org/licenses/odbl/1.0/ http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM http://purl.org/dc/terms/rightsHolder http://rdf.disgenet.org/v4.0.0/void/IBIGroup http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM http://purl.org/dc/terms/subject http://semanticscience.org/resource/SIO_000983 http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM http://purl.org/net/provenance/ns#usedData http://rdf.disgenet.org/v4.0.0/void/disgenetv3.0rdf http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM http://purl.org/pav/authoredBy http://orcid.org/0000-0001-5999-6269 http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM http://purl.org/pav/authoredBy http://orcid.org/0000-0002-7534-7661 http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM http://purl.org/pav/authoredBy http://orcid.org/0000-0002-9383-528X http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM http://purl.org/pav/authoredBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM http://purl.org/pav/authoredBy http://orcid.org/0000-0003-1244-7654 http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM http://purl.org/pav/createdBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/resource/nanopub/NP746728.RARws7LE5PdQ0APANuuV3y0s04mPQIn44c4I3dnKstDhM http://purl.org/pav/version v4.0.0.0 http://rdf.disgenet.org/v4.0.0/void/disgenetv3.0rdf http://purl.org/pav/version v4.0.0