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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RARcwg6o-fvU0GWvqX1vJyS7ShSGntif9qaXbqFR0kNMM#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RARcwg6o-fvU0GWvqX1vJyS7ShSGntif9qaXbqFR0kNMM#_5 http://www.w3.org/ns/prov#value Constitutive expression of Dlx-5 in ROS 17/2.8 cells decreased osteocalcin promoter activity in transient assays, and conditional expression of Dlx-5 in stable cell lines reduced endogenous mRNA levels. Consistent with this finding, antisense inhibition of Dlx-5 increased osteocalcin gene transcription. Osteocalcin promoter deletion analysis and binding of the in vitro translation product of Dlx-5 demonstrated that repressor activity was targeted to a single homeodomain-binding site, located in OC-Box I (-99 to -76).These findings demonstrate that Dlx-5 represses osteocalcin gene transcription. http://www.tkuhn.ch/bel2nanopub/RARcwg6o-fvU0GWvqX1vJyS7ShSGntif9qaXbqFR0kNMM#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/9328350 http://www.tkuhn.ch/bel2nanopub/RARcwg6o-fvU0GWvqX1vJyS7ShSGntif9qaXbqFR0kNMM#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RARcwg6o-fvU0GWvqX1vJyS7ShSGntif9qaXbqFR0kNMM#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/9328350 http://www.tkuhn.ch/bel2nanopub/RARcwg6o-fvU0GWvqX1vJyS7ShSGntif9qaXbqFR0kNMM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RARcwg6o-fvU0GWvqX1vJyS7ShSGntif9qaXbqFR0kNMM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RARcwg6o-fvU0GWvqX1vJyS7ShSGntif9qaXbqFR0kNMM#_5 http://www.tkuhn.ch/bel2nanopub/RARcwg6o-fvU0GWvqX1vJyS7ShSGntif9qaXbqFR0kNMM#pubinfo http://www.tkuhn.ch/bel2nanopub/RARcwg6o-fvU0GWvqX1vJyS7ShSGntif9qaXbqFR0kNMM http://purl.org/dc/terms/created 2014-07-03T14:34:01.847+02:00 http://www.tkuhn.ch/bel2nanopub/RARcwg6o-fvU0GWvqX1vJyS7ShSGntif9qaXbqFR0kNMM http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RARcwg6o-fvU0GWvqX1vJyS7ShSGntif9qaXbqFR0kNMM http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234