sub:provenance { beldoc:dce:description "Approximately 61,000 statements." ; dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ; dce:title "BEL Framework Large Corpus Document" ; pav:authoredBysub:_4 ; pav:version "20131211" . sub:_3prov:value "Expression of MuRF1 and MAFbx is stimulated when the nerve innervating a muscle is cut, thus resulting in paralysis and severe atrophy; these genes are also upregulated by simple immobilization of the muscle, or by treatment with a glucocorticoid, which causes muscle cachexia [11]. More recently, a predictive experiment was performed, in which sepsis-induced atrophy was induced to determine whether this distinct model of atrophy might also increase expression of MuRF1 and MAFbx. Both of these genes were upregulated several-fold during sepsis [72], and this upregulation could be blocked by a pharmacologic inhibitor of glucocorticoids [72]." ; prov:wasQuotedFrompubmed:12928036 . sub:_4rdfs:label "Selventa" . sub:assertionprov:hadPrimarySourcepubmed:12928036 ; prov:wasDerivedFrombeldoc: , sub:_3 . }