<http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4> <http://www.nanopub.org/nschema#hasAssertion> <http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#assertion> <http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#head> .
<http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4> <http://www.nanopub.org/nschema#hasProvenance> <http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#provenance> <http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#head> .
<http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4> <http://www.nanopub.org/nschema#hasPublicationInfo> <http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#publicationInfo> <http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#head> .
<http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.nanopub.org/nschema#Nanopublication> <http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#head> .
<http://bio2rdf.org/drugbank:DB06168> <http://bio2rdf.org/bio2rdf_vocabulary:identifier> "DB06168" <http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#assertion> .
<http://bio2rdf.org/drugbank:DB06168> <http://bio2rdf.org/bio2rdf_vocabulary:namespace> "drugbank" <http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#assertion> .
<http://bio2rdf.org/drugbank:DB06168> <http://bio2rdf.org/bio2rdf_vocabulary:uri> "http://bio2rdf.org/drugbank:DB06168" <http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#assertion> .
<http://bio2rdf.org/drugbank:DB06168> <http://bio2rdf.org/bio2rdf_vocabulary:x-identifiers.org> <http://identifiers.org/drugbank/DB06168> <http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#assertion> .
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<http://bio2rdf.org/drugbank:DB06168> <http://bio2rdf.org/drugbank_vocabulary:x-atc> <http://bio2rdf.org/atc:L04AC08> <http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#assertion> .
<http://bio2rdf.org/drugbank:DB06168> <http://bio2rdf.org/drugbank_vocabulary:x-cas> <http://bio2rdf.org/cas:914613-48-2> <http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#assertion> .
<http://bio2rdf.org/drugbank:DB06168> <http://bio2rdf.org/drugbank_vocabulary:x-kegg> <http://bio2rdf.org/kegg:D09315> <http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#assertion> .
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<http://bio2rdf.org/drugbank:DB06168> <http://purl.org/dc/terms/description> "Canakinumab is a recombinant, human anti-human-IL-1Î² monoclonal antibody that belongs to the IgG1/Îº isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. Both heavy chains of canakinumab contain oligosaccharide chains linked to the protein backbone at asparagine 298 (Asn 298). Canakinumab binds to human IL-1Î² and neutralizes its inflammatory activity by blocking its interaction with IL-1 receptors, but it does not bind IL-1alpha or IL-1 receptor antagonist (IL-1ra). Canakinumab is marketed under the brand name Ilaris and indicated for patients 4 years of age and older to treat Familial Cold Autoinflammatory Syndrome (FCAS) and Muckle-Wells Syndrome (MWS), which are both part of the Cryopyrin-Associated Periodic Syndromes (CAPS) as well as for patients 2 years of age and older to treat systemic juvenile idiopathic arthritis (SJIA). Clinical trials have established the administration of canakinumab every 2 weeks to be safe and effective, offering a considerable advantage over the existing treatment with the human IL-1 receptor antagonist, anakinra, which must be injected daily and which is often poorly tolerated by patients."@en <http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#assertion> .
<http://bio2rdf.org/drugbank:DB06168> <http://purl.org/dc/terms/identifier> "drugbank:DB06168" <http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#assertion> .
<http://bio2rdf.org/drugbank:DB06168> <http://purl.org/dc/terms/title> "Canakinumab"@en <http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#assertion> .
<http://bio2rdf.org/drugbank:DB06168> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://bio2rdf.org/drugbank_vocabulary:Drug> <http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#assertion> .
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<http://bio2rdf.org/drugbank:DB06168> <http://www.w3.org/2000/01/rdf-schema#seeAlso> <http://www.rxlist.com/ilaris-drug.htm> <http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#assertion> .
<http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#assertion> <http://www.w3.org/ns/prov#wasDerivedFrom> <http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz> <http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#provenance> .
<http://bio2rdf.org/drugbank_resource:bio2rdf.dataset.drugbank.R3> <http://www.w3.org/ns/dcat#distribution> <http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz> <http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#provenance> .
<http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz> <http://purl.org/dc/terms/created> "2015-01-09T17:00:50-05:00"^^<http://www.w3.org/2001/XMLSchema#dateTime> <http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#provenance> .
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<http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00> <http://purl.org/pav/retrievedOn> "2014-11-12T07:57:03-05:00"^^<http://www.w3.org/2001/XMLSchema#dateTime> <http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#provenance> .
<http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00> <http://www.w3.org/ns/prov#wasDerivedFrom> <http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip> <http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#provenance> .
<http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip> <http://www.w3.org/ns/prov#wasAttributedTo> <http://drugbank.ca> <http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#provenance> .
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<http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#signature.MCwCFCQebn0LSME-> <http://purl.org/nanopub/x/signedBy> <https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB> <http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#publicationInfo> .
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<http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4> <http://purl.org/nanopub/x/hasSignatureElement> <http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#signature.MCwCFCQebn0LSME-> <http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#publicationInfo> .
<http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4> <http://www.w3.org/ns/prov#wasGeneratedBy> <https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475> <http://bio2rdf.org/drugbank:DB06168_nanopub.RARbWoab9yznhxc9KJ1hdBZ3xAUcEIbRU20ek1FHfFSg4#publicationInfo> .
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