. . . . . . . . . . . . . . "a(SCHEM:Norepinephrine) => cat(p(RGD:Adra1b))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "Cardiovascular Physiology Concepts" . "Cardiovascular Physiology Concepts" . "Other" . "There are several signal transduction mechanisms that modulate intracellular calcium concentration and therefore the state of vascular tone. Three different mechanisms will be described here: 1) phosphatidylinositol pathway, 2) Gs-protein-coupled pathway, and 3) nitric oxide-cGMP pathway The phosphatidylinositol pathway (shown to the right) in VSM is similar to that found in the heart. Norepinephrine (NE) acting via a1-adrenoceptors, angiotensin II (AII) acting via AII receptors, and endothelin-I (ET-1) acting through ETA receptors activate phospholipase C (PL-C) causing the formation of inositol triphosphate (IP3) from phosphatidylinositol (PIP2)." . . "Selventa" . . . . "2014-07-03T14:31:29.044+02:00"^^ . . .