http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q#Head http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q#assertion http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q#provenance http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q#pubinfo http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q#assertion http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q#_1 http://purl.obolibrary.org/obo/RO_0002204 http://rgd.mcw.edu/rgdweb/report/gene/main.html?id=2889 http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10116 http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://amigo.geneontology.org/amigo/term/GO:0030431 http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q#_1 http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q#assertion http://www.w3.org/2000/01/rdf-schema#label p(RGD:Il18) -> bp(GOBP:sleep) http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q#_3 http://www.w3.org/ns/prov#value Interleukin (IL)-1beta is involved in physiological sleep regulation. IL-18 is a member of the IL-1 family, and its signal-transduction mechanism is similar to that of IL-1. Therefore, we hypothesized that IL-18 might also be involved in sleep regulation. Three doses of IL-18 (10, 100, and 500 ng) were injected intracerebroventricularly (icv) into rabbits at the onset of the dark period. The two higher doses of IL-18 markedly increased non-rapid eye movement sleep (NREMS), accompanied by increases in brain temperature (Tbr). These effects were lost after the heat inactivation of IL-18. The 500 ng of IL-18 injection during the light period also increased NREMS and Tbr. Similar results were obtained after icv injection of 100 ng of IL-18 into rats. Furthermore, intraperitoneal injection of 30 microg/kg of IL-18 slightly, but significantly, increased NREMS, whereas it significantly decreased electroencephalogram slow-wave activity in rats. Intraperitoneal IL-18 failed to induce fever. An anti-human IL-18 antibody had little effect on spontaneous sleep in rabbits, although the anti-IL-18 antibody significantly attenuated muramyl dipeptide-induced sleep. These data suggest that IL-18 is involved in mechanisms of sleep responses to infection. http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11506998 http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11506998 http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q#_3 http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q#pubinfo http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q http://purl.org/dc/terms/created 2014-07-03T14:31:43.193+02:00 http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RARGsU4xS6QufjaXnqChm2GR8s9uVnW4sVRfPo2xyBn8Q http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234