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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAREJ5OvgD33fv9LlUMRwjkcZACLiegeilvu-xRadsmMQ#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAREJ5OvgD33fv9LlUMRwjkcZACLiegeilvu-xRadsmMQ#_4 http://www.w3.org/ns/prov#value These cells are said to display a 'contractile/ quiescent' phenotype (Thyberg, 1998; Regan et al., 2000). In contrast, during development, or in response to cardiovascular stresses in the adult, VSMC and VEC undergo a process of phenotypic modulation that results in the development of cells with migratory and proliferative phenotypes. Such 'synthetic/ activated' VSMC and VEC are no longer contractile and become sensitive to the growth-promoting and chemoattractant influences of plasma- and cell-derived factors (e.g., platelet-derived growth factor) (Thyberg, 1998; Regan et al., 2000). Although PDE1A and PDE1B enzymes selectively hydrolyze cGMP, PDE1C variants hydrolyze both cAMP and cGMP with high affinity (Zhao et al., 1997). http://www.tkuhn.ch/bel2nanopub/RAREJ5OvgD33fv9LlUMRwjkcZACLiegeilvu-xRadsmMQ#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12920188 http://www.tkuhn.ch/bel2nanopub/RAREJ5OvgD33fv9LlUMRwjkcZACLiegeilvu-xRadsmMQ#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAREJ5OvgD33fv9LlUMRwjkcZACLiegeilvu-xRadsmMQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12920188 http://www.tkuhn.ch/bel2nanopub/RAREJ5OvgD33fv9LlUMRwjkcZACLiegeilvu-xRadsmMQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAREJ5OvgD33fv9LlUMRwjkcZACLiegeilvu-xRadsmMQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAREJ5OvgD33fv9LlUMRwjkcZACLiegeilvu-xRadsmMQ#_4 http://www.tkuhn.ch/bel2nanopub/RAREJ5OvgD33fv9LlUMRwjkcZACLiegeilvu-xRadsmMQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RAREJ5OvgD33fv9LlUMRwjkcZACLiegeilvu-xRadsmMQ http://purl.org/dc/terms/created 2014-07-03T14:32:06.860+02:00 http://www.tkuhn.ch/bel2nanopub/RAREJ5OvgD33fv9LlUMRwjkcZACLiegeilvu-xRadsmMQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAREJ5OvgD33fv9LlUMRwjkcZACLiegeilvu-xRadsmMQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234