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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RARDyNldxaEJOtjbqjKgQHHY9rMN3fkmV86CJ19QyZKLE#_7 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RARDyNldxaEJOtjbqjKgQHHY9rMN3fkmV86CJ19QyZKLE#_6 http://www.w3.org/ns/prov#value TLR4 and Syk were required for mmLDL activation of guanine nucleotide exchanging factor Vav1, small GTPase Ras, kinases Raf, MEK1 and ERK1/2; in turn, ERK1/2 phosphorylated paxillin at Ser126 and activated small GTPases Cdc42, Rac and Rho (Figure 3 and Online Figure III). These signaling events lead to actin polymerization, a necessary step in membrane ruffling. Our results agree with the reports of Syk-dependent ERK1/2 activation in phagocytosis45, ERK1/2 activation in TLR4-dependent antigen uptake by dendritic cells46, and the role of paxillin and small GTPases in actin reorganization and pinocytic vesicle formation9,26,27,47. http://www.tkuhn.ch/bel2nanopub/RARDyNldxaEJOtjbqjKgQHHY9rMN3fkmV86CJ19QyZKLE#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/19461045 http://www.tkuhn.ch/bel2nanopub/RARDyNldxaEJOtjbqjKgQHHY9rMN3fkmV86CJ19QyZKLE#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RARDyNldxaEJOtjbqjKgQHHY9rMN3fkmV86CJ19QyZKLE#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/19461045 http://www.tkuhn.ch/bel2nanopub/RARDyNldxaEJOtjbqjKgQHHY9rMN3fkmV86CJ19QyZKLE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RARDyNldxaEJOtjbqjKgQHHY9rMN3fkmV86CJ19QyZKLE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RARDyNldxaEJOtjbqjKgQHHY9rMN3fkmV86CJ19QyZKLE#_6 http://www.tkuhn.ch/bel2nanopub/RARDyNldxaEJOtjbqjKgQHHY9rMN3fkmV86CJ19QyZKLE#pubinfo http://www.tkuhn.ch/bel2nanopub/RARDyNldxaEJOtjbqjKgQHHY9rMN3fkmV86CJ19QyZKLE http://purl.org/dc/terms/created 2014-07-03T14:33:34.773+02:00 http://www.tkuhn.ch/bel2nanopub/RARDyNldxaEJOtjbqjKgQHHY9rMN3fkmV86CJ19QyZKLE http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RARDyNldxaEJOtjbqjKgQHHY9rMN3fkmV86CJ19QyZKLE http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234