http://www.tkuhn.ch/bel2nanopub/RARAY_iE6LexYoHIIqJxB6x_NjrnHgzwz26u8fOkvkpFk#Head http://www.tkuhn.ch/bel2nanopub/RARAY_iE6LexYoHIIqJxB6x_NjrnHgzwz26u8fOkvkpFk http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RARAY_iE6LexYoHIIqJxB6x_NjrnHgzwz26u8fOkvkpFk#assertion http://www.tkuhn.ch/bel2nanopub/RARAY_iE6LexYoHIIqJxB6x_NjrnHgzwz26u8fOkvkpFk http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RARAY_iE6LexYoHIIqJxB6x_NjrnHgzwz26u8fOkvkpFk#provenance http://www.tkuhn.ch/bel2nanopub/RARAY_iE6LexYoHIIqJxB6x_NjrnHgzwz26u8fOkvkpFk http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RARAY_iE6LexYoHIIqJxB6x_NjrnHgzwz26u8fOkvkpFk#pubinfo http://www.tkuhn.ch/bel2nanopub/RARAY_iE6LexYoHIIqJxB6x_NjrnHgzwz26u8fOkvkpFk http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RARAY_iE6LexYoHIIqJxB6x_NjrnHgzwz26u8fOkvkpFk#assertion http://resource.belframework.org/belframework/1.0/namespace/selventa-named-human-complexes/VWF%3AIb-V-IX%20complex http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0043234 http://www.tkuhn.ch/bel2nanopub/RARAY_iE6LexYoHIIqJxB6x_NjrnHgzwz26u8fOkvkpFk#_1 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.bioontology.org/ontology/MSH/D001792 http://www.tkuhn.ch/bel2nanopub/RARAY_iE6LexYoHIIqJxB6x_NjrnHgzwz26u8fOkvkpFk#_1 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RARAY_iE6LexYoHIIqJxB6x_NjrnHgzwz26u8fOkvkpFk#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://resource.belframework.org/belframework/1.0/namespace/selventa-named-human-complexes/VWF%3AIb-V-IX%20complex http://www.tkuhn.ch/bel2nanopub/RARAY_iE6LexYoHIIqJxB6x_NjrnHgzwz26u8fOkvkpFk#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RARAY_iE6LexYoHIIqJxB6x_NjrnHgzwz26u8fOkvkpFk#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://resource.belframework.org/belframework/1.0/namespace/selventa-legacy-diseases/response%20to%20shear%20stress http://www.tkuhn.ch/bel2nanopub/RARAY_iE6LexYoHIIqJxB6x_NjrnHgzwz26u8fOkvkpFk#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RARAY_iE6LexYoHIIqJxB6x_NjrnHgzwz26u8fOkvkpFk#assertion http://www.w3.org/2000/01/rdf-schema#label path(SDIS:"response to shear stress") -> complex(NCH:"VWF:Ib-V-IX complex") http://www.tkuhn.ch/bel2nanopub/RARAY_iE6LexYoHIIqJxB6x_NjrnHgzwz26u8fOkvkpFk#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RARAY_iE6LexYoHIIqJxB6x_NjrnHgzwz26u8fOkvkpFk#_3 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RARAY_iE6LexYoHIIqJxB6x_NjrnHgzwz26u8fOkvkpFk#_2 http://www.w3.org/ns/prov#value INTRODUCTION Introduction References ADHESION IS REQUIRED for cell growth, differentiation, survival, and function. Nowhere is this more evident than in the response to tissue injury, where vascular damage triggers reparative processes, such as hemostasis, inflammation, and wound healing. These processes depend on a coordinated series of cell adhesion and migration events by platelets, leukocytes, and vascular cells for their successful execution.1 Cell adhesion is mediated by a structurally diverse group of plasma membrane receptors, each exhibiting specialized ligand-binding properties that are needed for specific tasks in the injury response. For example, when blood flows through a damaged blood vessel, leukocytes slow down and roll on the endothelial surface as a consequence of the interaction of appropriate sialyl Lewis X-rich membrane glycoproteins on the leukocytes with selectins on the endothelial cells.2,3 Platelets also roll under conditions of high shear on perturbed endothelium4 as well as on denuded vascular surfaces, in the latter case through interactions of the platelet glycoprotein (GP) Ib-V-IX complex with von Willebrand factor (vWF) in the subendothelial matrix. http://www.tkuhn.ch/bel2nanopub/RARAY_iE6LexYoHIIqJxB6x_NjrnHgzwz26u8fOkvkpFk#_2 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/9531572 http://www.tkuhn.ch/bel2nanopub/RARAY_iE6LexYoHIIqJxB6x_NjrnHgzwz26u8fOkvkpFk#_3 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RARAY_iE6LexYoHIIqJxB6x_NjrnHgzwz26u8fOkvkpFk#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/9531572 http://www.tkuhn.ch/bel2nanopub/RARAY_iE6LexYoHIIqJxB6x_NjrnHgzwz26u8fOkvkpFk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RARAY_iE6LexYoHIIqJxB6x_NjrnHgzwz26u8fOkvkpFk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RARAY_iE6LexYoHIIqJxB6x_NjrnHgzwz26u8fOkvkpFk#_2 http://www.tkuhn.ch/bel2nanopub/RARAY_iE6LexYoHIIqJxB6x_NjrnHgzwz26u8fOkvkpFk#pubinfo http://www.tkuhn.ch/bel2nanopub/RARAY_iE6LexYoHIIqJxB6x_NjrnHgzwz26u8fOkvkpFk http://purl.org/dc/terms/created 2014-07-03T14:30:59.600+02:00 http://www.tkuhn.ch/bel2nanopub/RARAY_iE6LexYoHIIqJxB6x_NjrnHgzwz26u8fOkvkpFk http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RARAY_iE6LexYoHIIqJxB6x_NjrnHgzwz26u8fOkvkpFk http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234