http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#Head http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#assertion http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#provenance http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#pubinfo http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#assertion http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#_1 http://www.selventa.com/vocabulary/hasSubstitution D,281,G http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#_1 http://www.selventa.com/vocabulary/variantOf http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=11998 http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000 http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#_2 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#_3 http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0042789 http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#_3 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=12003 http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#_2 http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/directlyDecreases http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#_1 http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#assertion http://www.w3.org/2000/01/rdf-schema#label p(HGNC:TP53,sub(D,281,G)) =| tscript(p(HGNC:TP73)) http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#_5 http://www.w3.org/ns/prov#value Despite these limitations, three categories of GOF have been selected, where data were available for more than 50 distinct mutants and for more than 70 experiments measuring: 1) interference with p73 activity; 2) transactivation of genes repressed by wild-type p53; and 3) cooperation with oncogene for transformation of rat embryonic fibroblast (REF) or mouse embryonic fibroblast (MEF) cells (Supplementary Table S2).For example, R175H, which is the most frequently reported mutant (reported 944 times), has GOF properties in all categories. However, two rare (reported less than 20 times) mutants, V143A and D281G, have also been shown to have GOF properties in the three categories. http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17311302 http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17311302 http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#_5 http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#pubinfo http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo http://purl.org/dc/terms/created 2014-07-03T14:33:08.556+02:00 http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234