@prefix this: <http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RARAF2w7NO7Vw1p_lMRKBnQX1S-L7J3crjuRPCG_QjTOo#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix proteinModification: <http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 belv:hasSubstitution "D,281,G";
    belv:variantOf hgnc:11998;
    a proteinModification: .
  
  sub:_2 hasAgent: sub:_3;
    a go:0042789 .
  
  sub:_3 geneProductOf: hgnc:12003;
    a Protein: .
  
  sub:_4 occursIn: species:9606;
    rdf:object sub:_2;
    rdf:predicate belv:directlyDecreases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "p(HGNC:TP53,sub(D,281,G)) =| tscript(p(HGNC:TP73))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_6;
    pav:version "20131211" .
  
  sub:_5 prov:value "Despite these limitations, three categories of GOF have been selected, where data were available for more than 50 distinct mutants and for more than 70 experiments measuring: 1) interference with p73 activity; 2) transactivation of genes repressed by wild-type p53; and 3) cooperation with oncogene for transformation of rat embryonic fibroblast (REF) or mouse embryonic fibroblast (MEF) cells (Supplementary Table S2).For example, R175H, which is the most frequently reported mutant (reported 944 times), has GOF properties in all categories. However, two rare (reported less than 20 times) mutants, V143A and D281G, have also been shown to have GOF properties in the three categories.";
    prov:wasQuotedFrom pubmed:17311302 .
  
  sub:_6 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:17311302;
    prov:wasDerivedFrom beldoc:, sub:_5 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:33:08.556+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}