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[Significant genes in myeloma plasma cells from patients that were associated with early-onset bortezomib-induced peripheral neuropathy were the enzyme coding genes RHOBTB2 (upregulated by 1�59 times; p=4�5�10(-5)), involved in drug-induced apoptosis, CPT1C (1�44 times; p=2�9�10(-7)), involved in mitochondrial dysfunction, and SOX8 (1�68 times; p=4�28�10(-13)), involved in development of peripheral nervous system.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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DisGeNET evidence - CURATED
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