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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAR6T7egyyZFcnPduz48IH-adAC8cquyox9NtJQsuKWgY#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAR6T7egyyZFcnPduz48IH-adAC8cquyox9NtJQsuKWgY#_5 http://www.w3.org/ns/prov#value We present evidence for an equally important role of KLF4 in maintaining the integrity of the G2/M checkpoint following DNA damage. HCT116, a colon cancer cell line with wild type p53 alleles, underwent sustained G2 arrest up to 4 days after gamma-irradiation. In contrast, HCT116 cells null for p53 were able to enter mitosis following irradiation. Western blot analyses of irradiated HCT116 cells showed increased levels of p53, KLF4, and p21WAF1/CIP1 and decreased levels of cyclin B1 when compared with unirradiated controls. In contrast, the levels of cyclin B1 increased in irradiated HCT116 p53-/- cells, in which KLF4 failed to increase due to the absence of p53. http://www.tkuhn.ch/bel2nanopub/RAR6T7egyyZFcnPduz48IH-adAC8cquyox9NtJQsuKWgY#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/14627709 http://www.tkuhn.ch/bel2nanopub/RAR6T7egyyZFcnPduz48IH-adAC8cquyox9NtJQsuKWgY#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAR6T7egyyZFcnPduz48IH-adAC8cquyox9NtJQsuKWgY#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/14627709 http://www.tkuhn.ch/bel2nanopub/RAR6T7egyyZFcnPduz48IH-adAC8cquyox9NtJQsuKWgY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAR6T7egyyZFcnPduz48IH-adAC8cquyox9NtJQsuKWgY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAR6T7egyyZFcnPduz48IH-adAC8cquyox9NtJQsuKWgY#_5 http://www.tkuhn.ch/bel2nanopub/RAR6T7egyyZFcnPduz48IH-adAC8cquyox9NtJQsuKWgY#pubinfo http://www.tkuhn.ch/bel2nanopub/RAR6T7egyyZFcnPduz48IH-adAC8cquyox9NtJQsuKWgY http://purl.org/dc/terms/created 2014-07-03T14:32:12.224+02:00 http://www.tkuhn.ch/bel2nanopub/RAR6T7egyyZFcnPduz48IH-adAC8cquyox9NtJQsuKWgY http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAR6T7egyyZFcnPduz48IH-adAC8cquyox9NtJQsuKWgY http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234