. . . . . . . . . . . . . . . . . "bp(GOBP:\"cellular response to DNA damage stimulus\") -| bp(GOBP:\"G2/M transition of mitotic cell cycle\")" . "tscript(p(HGNC:KLF4)) -> (bp(GOBP:\"cellular response to DNA damage stimulus\") -| bp(GOBP:\"G2/M transition of mitotic cell cycle\"))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "We present evidence for an equally important role of KLF4 in maintaining the integrity of the G2/M checkpoint following DNA damage. HCT116, a colon cancer cell line with wild type p53 alleles, underwent sustained G2 arrest up to 4 days after gamma-irradiation. In contrast, HCT116 cells null for p53 were able to enter mitosis following irradiation. Western blot analyses of irradiated HCT116 cells showed increased levels of p53, KLF4, and p21WAF1/CIP1 and decreased levels of cyclin B1 when compared with unirradiated controls. In contrast, the levels of cyclin B1 increased in irradiated HCT116 p53-/- cells, in which KLF4 failed to increase due to the absence of p53." . . "Selventa" . . . . "2014-07-03T14:32:12.224+02:00"^^ . . .