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Approximately 61,000 statements.
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In contrast, the DNA binding activity of Smad3/4 was up-regulated by GSK-3{alpha} siRNA and appeared to be unaffected by GSK-3beta siRNA. Moreover, the activity of Smad3/4-responsive transcription was enhanced by GSK-3{alpha} siRNA and its dominant negative mutant but slightly reduced by GSK-3beta siRNA and its R96A mutant (Fig. 4B).
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