[ { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAR54K7ruoa6OstJIYjc0hBn7AT9t8PZv2wWMt9BXN_cU", "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ], "http://www.nanopub.org/nschema#hasAssertion" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAR54K7ruoa6OstJIYjc0hBn7AT9t8PZv2wWMt9BXN_cU#assertion" } ], "http://www.nanopub.org/nschema#hasProvenance" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAR54K7ruoa6OstJIYjc0hBn7AT9t8PZv2wWMt9BXN_cU#provenance" } ], "http://www.nanopub.org/nschema#hasPublicationInfo" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAR54K7ruoa6OstJIYjc0hBn7AT9t8PZv2wWMt9BXN_cU#pubinfo" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAR54K7ruoa6OstJIYjc0hBn7AT9t8PZv2wWMt9BXN_cU#Head" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAR54K7ruoa6OstJIYjc0hBn7AT9t8PZv2wWMt9BXN_cU#_1", "@type" : [ "http://amigo.geneontology.org/amigo/term/GO:0016301" ], "http://semanticscience.org/resource/SIO_000139" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAR54K7ruoa6OstJIYjc0hBn7AT9t8PZv2wWMt9BXN_cU#_2" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAR54K7ruoa6OstJIYjc0hBn7AT9t8PZv2wWMt9BXN_cU#_2", "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080" ], "http://purl.obolibrary.org/obo/RO_0002204" : [ { "@id" : "http://www.informatics.jax.org/marker/MGI:96433" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAR54K7ruoa6OstJIYjc0hBn7AT9t8PZv2wWMt9BXN_cU#_3", "@type" : [ "http://amigo.geneontology.org/amigo/term/GO:0003824" ], "http://semanticscience.org/resource/SIO_000139" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAR54K7ruoa6OstJIYjc0hBn7AT9t8PZv2wWMt9BXN_cU#_4" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAR54K7ruoa6OstJIYjc0hBn7AT9t8PZv2wWMt9BXN_cU#_4", "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080" ], "http://purl.obolibrary.org/obo/RO_0002204" : [ { "@id" : "http://www.informatics.jax.org/marker/MGI:109334" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAR54K7ruoa6OstJIYjc0hBn7AT9t8PZv2wWMt9BXN_cU#_5", "@type" : [ "http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement" ], "http://purl.obolibrary.org/obo/BFO_0000066" : [ { "@id" : "http://purl.bioontology.org/ontology/MSH/D005347" }, { "@id" : "http://purl.bioontology.org/ontology/MSH/D008168" }, { "@id" : "http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#object" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAR54K7ruoa6OstJIYjc0hBn7AT9t8PZv2wWMt9BXN_cU#_3" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate" : [ { "@id" : "http://www.selventa.com/vocabulary/increases" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAR54K7ruoa6OstJIYjc0hBn7AT9t8PZv2wWMt9BXN_cU#_1" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAR54K7ruoa6OstJIYjc0hBn7AT9t8PZv2wWMt9BXN_cU#assertion", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "kin(p(MGI:Igf1r)) -> cat(p(MGI:Irs2))" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAR54K7ruoa6OstJIYjc0hBn7AT9t8PZv2wWMt9BXN_cU#assertion" }, { "@graph" : [ { "@id" : "http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel", "http://purl.org/dc/elements/1.1/description" : [ { "@value" : "Approximately 61,000 statements." } ], "http://purl.org/dc/elements/1.1/rights" : [ { "@value" : "Copyright (c) 2011-2012, Selventa. All rights reserved." } ], "http://purl.org/dc/elements/1.1/title" : [ { "@value" : "BEL Framework Large Corpus Document" } ], "http://purl.org/pav/authoredBy" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAR54K7ruoa6OstJIYjc0hBn7AT9t8PZv2wWMt9BXN_cU#_7" } ], "http://purl.org/pav/version" : [ { "@value" : "1.4" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAR54K7ruoa6OstJIYjc0hBn7AT9t8PZv2wWMt9BXN_cU#_6", "http://www.w3.org/ns/prov#value" : [ { "@value" : "We examined the effect of blockade of type 1 IGF tyrosine kinase receptor (IGF-IR) in a murine model of bleomycin-induced lung injury and fibrosis. Mice were treated with a monoclonal antibody against the IGF-I receptor (A12) or vehicle after intratracheal bleomycin instillation. MEASUREMENTS AND MAIN RESULTS: Mice treated with A12 antibody had significantly improved survival after bleomycin injury compared with control mice. Both groups of mice had a similar degree of fibrosis on days 7 and 14, but by Day 28 the A12-treated group had significantly less fibrosis. Delayed treatment with A12 also resulted in decreased fibrosis. A12-treated mice had significantly decreased apoptotic cells on Day 28 compared with control mice. We confirmed that A12 treatment induced mouse lung fibroblast apoptosis in vitro. In addition, IGF-I increased lung fibroblast migration. The primary pathway activated by IGF-I in lung fibroblasts was the insulin receptor substrate-2/phosphatidylinositol 3-kinase/Akt axis." } ], "http://www.w3.org/ns/prov#wasQuotedFrom" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/19011156" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAR54K7ruoa6OstJIYjc0hBn7AT9t8PZv2wWMt9BXN_cU#_7", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "Selventa" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAR54K7ruoa6OstJIYjc0hBn7AT9t8PZv2wWMt9BXN_cU#assertion", "http://www.w3.org/ns/prov#hadPrimarySource" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/19011156" } ], "http://www.w3.org/ns/prov#wasDerivedFrom" : [ { "@id" : "http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel" }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAR54K7ruoa6OstJIYjc0hBn7AT9t8PZv2wWMt9BXN_cU#_6" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAR54K7ruoa6OstJIYjc0hBn7AT9t8PZv2wWMt9BXN_cU#provenance" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAR54K7ruoa6OstJIYjc0hBn7AT9t8PZv2wWMt9BXN_cU", "http://purl.org/dc/terms/created" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#dateTime", "@value" : "2014-07-03T14:30:53.946+02:00" } ], "http://purl.org/pav/createdBy" : [ { "@id" : "http://orcid.org/0000-0001-6818-334X" }, { "@id" : "http://orcid.org/0000-0002-1267-0234" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAR54K7ruoa6OstJIYjc0hBn7AT9t8PZv2wWMt9BXN_cU#pubinfo" } ]