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http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAR0uyaJeNUwdf_MB2wJ9W0VLdeknvQnu0GB3kqAq_OJY#_9 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAR0uyaJeNUwdf_MB2wJ9W0VLdeknvQnu0GB3kqAq_OJY#_8 http://www.w3.org/ns/prov#value In these cells, three major p85-containing complexes were formed after EGF treatment: ErbB3-p85, Shc-p85, and a multimeric Gab2-Grb2-SHP2-p85, which accounted for more than 80% of total EGF-induced PI3K activity (Kong, M., C. Mounier, J. Wu, and B. I. Posner, J Biol Chem, 2000, 275:36035-36042). More recently, we found that EGF-dependent tyrosine phosphorylation of endogenous Gab2 is essential for EGF-induced DNA synthesis in rat hepatocytes. Here we show that, after EGF treatment, ErbB3-p85 and Shc-p85 complexes were localized to plasma membrane and endosomes, whereas the multimeric Gab2-Grb2-SHP2-p85 complex was formed rapidly (peak at 30 sec) and exclusively in cytosol. http://www.tkuhn.ch/bel2nanopub/RAR0uyaJeNUwdf_MB2wJ9W0VLdeknvQnu0GB3kqAq_OJY#_8 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12595575 http://www.tkuhn.ch/bel2nanopub/RAR0uyaJeNUwdf_MB2wJ9W0VLdeknvQnu0GB3kqAq_OJY#_9 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAR0uyaJeNUwdf_MB2wJ9W0VLdeknvQnu0GB3kqAq_OJY#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12595575 http://www.tkuhn.ch/bel2nanopub/RAR0uyaJeNUwdf_MB2wJ9W0VLdeknvQnu0GB3kqAq_OJY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAR0uyaJeNUwdf_MB2wJ9W0VLdeknvQnu0GB3kqAq_OJY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAR0uyaJeNUwdf_MB2wJ9W0VLdeknvQnu0GB3kqAq_OJY#_8 http://www.tkuhn.ch/bel2nanopub/RAR0uyaJeNUwdf_MB2wJ9W0VLdeknvQnu0GB3kqAq_OJY#pubinfo http://www.tkuhn.ch/bel2nanopub/RAR0uyaJeNUwdf_MB2wJ9W0VLdeknvQnu0GB3kqAq_OJY http://purl.org/dc/terms/created 2014-07-03T14:31:59.220+02:00 http://www.tkuhn.ch/bel2nanopub/RAR0uyaJeNUwdf_MB2wJ9W0VLdeknvQnu0GB3kqAq_OJY http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAR0uyaJeNUwdf_MB2wJ9W0VLdeknvQnu0GB3kqAq_OJY http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234