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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAQscIly7Gyca5Pi2_88VjUWk_cio177XaqOaa75r-MBk#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAQscIly7Gyca5Pi2_88VjUWk_cio177XaqOaa75r-MBk#_5 http://www.w3.org/ns/prov#value We analyzed here the possible role of the tyrosine 769 in KGFR, corresponding to tyrosine 766 in FGFR1, in the regulation of KGFR signal transduction and MAPK activation as well as in the control of the endocytic process of KGFR. A mutant KGFR in which tyrosine 769 was substituted by phenylalanine was generated and transfected in NIH3T3 and HeLa cells. Our results indicate that tyrosine 769 is required for the binding to KGFR and tyrosine phosphorylation of PLCgamma as well as for the full activation of MAPKs and for cell proliferation through the regulation of FRS2 tyrosine phosphorylation http://www.tkuhn.ch/bel2nanopub/RAQscIly7Gyca5Pi2_88VjUWk_cio177XaqOaa75r-MBk#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15629145 http://www.tkuhn.ch/bel2nanopub/RAQscIly7Gyca5Pi2_88VjUWk_cio177XaqOaa75r-MBk#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAQscIly7Gyca5Pi2_88VjUWk_cio177XaqOaa75r-MBk#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15629145 http://www.tkuhn.ch/bel2nanopub/RAQscIly7Gyca5Pi2_88VjUWk_cio177XaqOaa75r-MBk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAQscIly7Gyca5Pi2_88VjUWk_cio177XaqOaa75r-MBk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAQscIly7Gyca5Pi2_88VjUWk_cio177XaqOaa75r-MBk#_5 http://www.tkuhn.ch/bel2nanopub/RAQscIly7Gyca5Pi2_88VjUWk_cio177XaqOaa75r-MBk#pubinfo http://www.tkuhn.ch/bel2nanopub/RAQscIly7Gyca5Pi2_88VjUWk_cio177XaqOaa75r-MBk http://purl.org/dc/terms/created 2014-07-03T14:32:37.271+02:00 http://www.tkuhn.ch/bel2nanopub/RAQscIly7Gyca5Pi2_88VjUWk_cio177XaqOaa75r-MBk http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAQscIly7Gyca5Pi2_88VjUWk_cio177XaqOaa75r-MBk http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234