dgn-np:NP326167.RAQs0urjE-Iz90NHf9Qc4GiL8OIWSDhAnvfBK3xi6so30130_provenance {
  dgn-np:NP326167.RAQs0urjE-Iz90NHf9Qc4GiL8OIWSDhAnvfBK3xi6so30130_assertion dcterms:description "[The proposed mechanism is supported by several pieces of evidence including: (1) the absolute essentiality of an intact unfolded protein response (UPR) machinery for survival of pancreatic beta-cells, (2) the high susceptibility of beta-cells to prolonged ER stress leading to induction of pro-apoptotic factors and apoptosis pathways in beta-cells, (3) CF patients with mutations in CFTR gene that are engaging the ER quality control system (ERAD) and hence UPR signalling are twenty time more likely to develop diabetes than those with other types of CF-causing mutations, and (4) the high levels of CFTR gene expression in pancreatic islet cells.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en ;
    wi:evidence dgn-void:source_evidence_literature ;
    sio:SIO_000772 miriam-pubmed:18851900 ;
    prov:wasDerivedFrom dgn-void:befree-20140225 ;
    prov:wasGeneratedBy eco:ECO_0000203 .
  dgn-void:befree-20140225 pav:importedOn "2014-02-25"^^xsd:date .
  dgn-void:source_evidence_literature a eco:ECO_0000212 ;
    rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en ;
    rdfs:label "DisGeNET evidence - LITERATURE"@en .
}